PMID- 21097318
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20200928
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2010
DP  - 2010
TI  - Brain activation in complex partial seizures during switching from a the 
      goal-directed task to a resting state: comparison of fMRI maps to the default 
      mode network.
PG  - 5685-8
LID - 10.1109/IEMBS.2010.5627883 [doi]
AB  - The default mode network (DMN) has been previously identified as a set of brain 
      regions activated during internally directed cognition. The objective of this 
      study was to investigate patterns of brain activation during switching between a 
      goal-directed task and a rest period obtained from clinical functional magnetic 
      resonance imaging (fMRI) paradigms in complex partial seizures (CPS) and 
      age-matched controls. As part of pre-surgical evaluation with fMRI, a visually 
      presented block-design language task was performed by eight subjects (4 CPS, 4 
      age-matched controls). Single subject fMRI maps were calculated and transferred 
      into Talairach space for an atlas-based analysis. For the rest state, total 
      volumes of activation, brain regions with largest volume of activation and 
      regions commonly activated in the CPS and the control group were identified. A 
      voxel-by-voxel comparison was conducted to reveal inter-group statistically 
      significant differences. Average volume of activation in the CPS group was 
      significantly higher (32,080 mm(3)) than in the control group (7,915 mm(3), 
      p-value < 0.03). In both groups, most of the common activation volume (81% in the 
      CPS group and 98 % in the control group) was located in cognitive regions of the 
      frontal lobe and temporal lobes as well as anterior cingulate cortex, precuneus 
      and cuneus. The remaining 19% in the CPS group included regions in the precentral 
      gyrus, the superior and medial occipital gyrus, the parahippocampal gyrus, the 
      inferior parietal lobule and the angular gyrus. The voxel-by-voxel comparison 
      showed larger areas of activation mostly in the frontal and temporal lobes in the 
      CPS group (as well as in the cuneus and precuneus), while regions with larger 
      activation in the control group were found mostly in the parietal lobe. Our 
      findings implicate that switching from goal-directed behavior to the default mode 
      in CPS patients is impaired. Information contained in clinical fMRI block-design 
      image data can be used to quantify this impairment.
FAU - Karmonik, Christof
AU  - Karmonik C
AD  - The Methodist Hospital Neurological Institute, Houston, TX 77030, USA. 
      ckarmonik@tmh.tmc.edu
FAU - Dulay, Mario
AU  - Dulay M
FAU - Verma, Amit
AU  - Verma A
FAU - Yen, Christopher
AU  - Yen C
FAU - Grossman, Robert G
AU  - Grossman RG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Brain/*physiopathology
MH  - Brain Mapping/*methods
MH  - Case-Control Studies
MH  - Epilepsy, Complex Partial/*physiopathology
MH  - *Goals
MH  - Humans
MH  - Language Tests
MH  - Magnetic Resonance Imaging/*methods
MH  - Organ Specificity
MH  - Rest/*physiology
MH  - *Task Performance and Analysis
EDAT- 2010/11/26 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 10.1109/IEMBS.2010.5627883 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5685-8. doi: 
      10.1109/IEMBS.2010.5627883.