PMID- 21097844
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110405
IS  - 1468-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 60
IP  - 5
DP  - 2011 May
TI  - Long-term proton pump inhibitor administration worsens atrophic corpus gastritis 
      and promotes adenocarcinoma development in Mongolian gerbils infected with 
      Helicobacter pylori.
PG  - 624-30
LID - 10.1136/gut.2010.207662 [doi]
AB  - BACKGROUND: We investigated whether corpus atrophic gastritis worsens in 
      Mongolian gerbils (MGs) after long-term administration of proton pump inhibitor 
      (PPI). MGs are an excellent model for studying Helicobacter pylori-related 
      gastritis and adenocarcinoma. METHODS: MGs were separated into four groups (n 
      =15/group); H pylori (ATCC43504) was inoculated into the OPZ(omeprazole)+Hp (H 
      pylori) and Hp groups, a PPI (OPZ) was administered to the OPZ+Hp and OPZ groups 
      and the control group received no treatment. MGs had access to food containing 
      omeprazole (100 mg/kg body weight/day) for 6 months, after which their stomachs 
      were removed and cut into nine sections (six sections in the fundus and three 
      sections in the antrum). Corpus atrophy was evaluated by the absence of parietal 
      cells in the six sections in the fundus. First, we calculated a percentage of the 
      area devoid of parietal cells in each haematoxylin and eosin-stained section, and 
      then we scored the degree of atrophy by adding the percentages of the six 
      sections. A full score was 600. RESULTS: Neutrophilic and lymphoid infiltrates 
      were greater in the OPZ+Hp group than in the other groups. The corpus atrophy 
      score in the OPZ+Hp group was significantly higher than that in the Hp group (p < 
      0.0048, Student t test). Significantly more adenocarcinomas were found in the 
      OPZ+Hp (60%) than in the Hp (7%) group animals. CONCLUSION: Long-term PPI 
      administration promotes development of adenocarcinoma, which is associated with 
      the progression of atrophic corpus gastritis in MGs infected with H pylori.
FAU - Hagiwara, Tadashi
AU  - Hagiwara T
AD  - Department of Pathology, Shiga University of Medical Science, Seta-tsukinowa-cho, 
      Otsu, Shiga 520-2192, Japan.
FAU - Mukaisho, Ken-Ichi
AU  - Mukaisho K
FAU - Nakayama, Takahisa
AU  - Nakayama T
FAU - Sugihara, Hiroyuki
AU  - Sugihara H
FAU - Hattori, Takanori
AU  - Hattori T
LA  - eng
PT  - Journal Article
DEP - 20101120
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Gastrins)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Gut. 2011 May;60(5):567-8. PMID: 21330575
MH  - Adenocarcinoma/*chemically induced/microbiology
MH  - Animals
MH  - Body Weight
MH  - Cocarcinogenesis
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Drug Administration Schedule
MH  - Gastrins/blood
MH  - Gastritis, Atrophic/chemically induced/microbiology/pathology
MH  - Gerbillinae
MH  - Helicobacter Infections/*complications
MH  - *Helicobacter pylori
MH  - Male
MH  - Metaplasia/chemically induced/microbiology
MH  - Proton Pump Inhibitors/administration & dosage/*toxicity
MH  - Stomach/pathology
MH  - Stomach Neoplasms/*chemically induced/microbiology
EDAT- 2010/11/26 06:00
MHDA- 2011/07/23 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - gut.2010.207662 [pii]
AID - 10.1136/gut.2010.207662 [doi]
PST - ppublish
SO  - Gut. 2011 May;60(5):624-30. doi: 10.1136/gut.2010.207662. Epub 2010 Nov 20.