PMID- 21098081
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20101224
IS  - 1471-8405 (Electronic)
IS  - 0962-7480 (Linking)
VI  - 61
IP  - 1
DP  - 2011 Jan
TI  - Smoking status and immunoglobulin E seropositivity to workplace allergens.
PG  - 62-4
LID - 10.1093/occmed/kqq171 [doi]
AB  - BACKGROUND: Detection of serum-specific immunoglobulin E (IgE) can be helpful in 
      the diagnosis of work-related allergic conditions. There have been conflicting 
      reports regarding any association between smoking and specific IgE levels. AIMS: 
      To establish whether a relationship exists between smoking status and the outcome 
      of specific IgE tests to workplace allergens. METHODS: The Health and Safety 
      Laboratory provides test services for workplace allergens and the request form 
      used collects data on smoking status. Laboratory results of 695 subjects who had 
      undergone specific IgE tests were examined by information on smoking. RESULTS: 
      Smokers were more likely than non-smokers to have positive specific IgE tests (P 
      < 0.05). Smoking was the only independent predictor of a positive specific IgE 
      test in logistic regression, with odds ratio of 2.39 (95% confidence interval 
      1.01-5.65, P < 0.05) for IgE seropositivity. Allergen subgroups also showed a 
      positive association with smoking and in particular for high molecular weight 
      allergens. CONCLUSIONS: Being a current smoker is a risk factor for sensitization 
      to workplace allergens especially for those of high molecular weight. Workplace 
      well-being activities may make use of such information for smoking cessation 
      programmes and emphasizing the importance of allergen exposure control. 
      Collaboration between testing laboratories may provide useful datasets for 
      further analysis.
FAU - Adisesh, A
AU  - Adisesh A
AD  - Centre for Workplace Health, Health and Safety Laboratory, Buxton SK17 9JN, UK.
FAU - Gruszka, L
AU  - Gruszka L
FAU - Robinson, E
AU  - Robinson E
FAU - Evans, G
AU  - Evans G
LA  - eng
PT  - Journal Article
DEP - 20101122
PL  - England
TA  - Occup Med (Lond)
JT  - Occupational medicine (Oxford, England)
JID - 9205857
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/classification/*immunology
MH  - Asthma/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/*immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Occupational Exposure/*adverse effects
MH  - Risk Factors
MH  - Smoking/blood/*immunology
EDAT- 2010/11/26 06:00
MHDA- 2011/09/17 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - kqq171 [pii]
AID - 10.1093/occmed/kqq171 [doi]
PST - ppublish
SO  - Occup Med (Lond). 2011 Jan;61(1):62-4. doi: 10.1093/occmed/kqq171. Epub 2010 Nov 
      22.