PMID- 21098580
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20151119
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Telemedical Interventional Monitoring in Heart Failure (TIM-HF), a randomized, 
      controlled intervention trial investigating the impact of telemedicine on 
      mortality in ambulatory patients with heart failure: study design.
PG  - 1354-62
LID - 10.1093/eurjhf/hfq199 [doi]
AB  - Remote patient management (telemonitoring) may help to detect early signs of 
      cardiac decompensation, allowing optimization of and adherence to treatments in 
      chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine 
      in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to 
      investigate the impact of telemedical management on mortality in ambulatory CHF 
      patients. Methods CHF patients [New York Heart Association (NYHA) II/III, left 
      ventricular ejection fraction (LVEF)</=35%] with a history of cardiac 
      decompensation with hospitalization in the past or therapy with intravenous 
      diuretics in the prior 24 months (no decompensation required if LVEF</=25%) were 
      randomized 1:1 to an intervention group of daily remote device monitoring 
      (electrocardiogram, blood pressure, body weight) coupled with medical telephone 
      support or to usual care led by the patients' local physician. In the 
      intervention group, 24/7 physician-led medical support was provided by two 
      central telemedical centres. A clinical event committee blinded to treatment 
      allocation assessed cause of death and reason for hospitalization. The primary 
      endpoint was total mortality. The first secondary endpoint was a composite of 
      cardiovascular mortality or hospitalization due to heart failure. Other secondary 
      endpoints included cardiovascular mortality, all-cause and cause-specific 
      hospitalizations (all time to first event) as well as days lost due to heart 
      failure hospitalization or cardiovascular death (in % of follow-up time), and 
      changes in quality of life and NYHA class. Overall, 710 CHF patients were 
      recruited. The mean follow-up was 21.5+/-7.2 months, with a minimum of 12 months. 
      Perspective The study will provide important prospective outcome data on the 
      impact of telemedical management in patients with CHF.
FAU - Koehler, Friedrich
AU  - Koehler F
AD  - Department of Cardiology and Angiology, Centre for Cardiovascular Telemedicine, 
      Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany. 
      friedrich.koehler@charite.de
FAU - Winkler, Sebastian
AU  - Winkler S
FAU - Schieber, Michael
AU  - Schieber M
FAU - Sechtem, Udo
AU  - Sechtem U
FAU - Stangl, Karl
AU  - Stangl K
FAU - Bohm, Michael
AU  - Bohm M
FAU - Boll, Herbert
AU  - Boll H
FAU - Kim, Simone S
AU  - Kim SS
FAU - Koehler, Kerstin
AU  - Koehler K
FAU - Lucke, Stephanie
AU  - Lucke S
FAU - Honold, Marcus
AU  - Honold M
FAU - Heinze, Peter
AU  - Heinze P
FAU - Schweizer, Thomas
AU  - Schweizer T
FAU - Braecklein, Martin
AU  - Braecklein M
FAU - Kirwan, Bridget-Anne
AU  - Kirwan BA
FAU - Gelbrich, Goetz
AU  - Gelbrich G
FAU - Anker, Stefan D
AU  - Anker SD
CN  - TIM-HF Investigators
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Algorithms
MH  - Ambulatory Care
MH  - Analysis of Variance
MH  - Antihypertensive Agents/therapeutic use
MH  - Confidence Intervals
MH  - Female
MH  - Germany/epidemiology
MH  - Heart Failure/drug therapy/epidemiology/*mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Multivariate Analysis
MH  - Psychometrics
MH  - Quality of Life/psychology
MH  - Risk
MH  - Surveys and Questionnaires
MH  - Telemedicine/*methods/organization & administration
FIR - Abele, Peter
IR  - Abele P
FIR - Aigeldinger, Erwin
IR  - Aigeldinger E
FIR - Anders, Carola
IR  - Anders C
FIR - Andre, Thomas
IR  - Andre T
FIR - Arend, Ute
IR  - Arend U
FIR - Asci, Tayfun
IR  - Asci T
FIR - Assenov-Lammert, Dorothea
IR  - Assenov-Lammert D
FIR - Bassen-auf dem Brinke, Alexandra
IR  - Bassen-auf dem Brinke A
FIR - Bauer, Gerhard
IR  - Bauer G
FIR - Becker, Hans-Joachim
IR  - Becker HJ
FIR - Behroz, Abdullah
IR  - Behroz A
FIR - Beling, Mark
IR  - Beling M
FIR - Biewener, Hans-Ullrich
IR  - Biewener HU
FIR - Boden, Ulrich
IR  - Boden U
FIR - Boitz, Martin
IR  - Boitz M
FIR - Bondke, Christina
IR  - Bondke C
FIR - Boron, Janusz
IR  - Boron J
FIR - Borst, Ulrich
IR  - Borst U
FIR - Brendel, Ralph
IR  - Brendel R
FIR - Brunk, Katharina
IR  - Brunk K
FIR - Bubeck, Otto
IR  - Bubeck O
FIR - Buhr, Marianne
IR  - Buhr M
FIR - Byrtus, Martin
IR  - Byrtus M
FIR - Dempe, Christophe
IR  - Dempe C
FIR - Dieckmann, Lutz
IR  - Dieckmann L
FIR - Doster, Gerhard
IR  - Doster G
FIR - Drescher, Matthias
IR  - Drescher M
FIR - Ehlert, Annette
IR  - Ehlert A
FIR - Elser, Kurt
IR  - Elser K
FIR - Engelsing, Meike
IR  - Engelsing M
FIR - Etzold, Erika
IR  - Etzold E
FIR - Fassbender, Manuel
IR  - Fassbender M
FIR - Finsterbusch, Frank
IR  - Finsterbusch F
FIR - Frank, Thomas
IR  - Frank T
FIR - Friedmann, Hans-Helmut
IR  - Friedmann HH
FIR - Frille, Angelika
IR  - Frille A
FIR - Gabelmann, Matthias
IR  - Gabelmann M
FIR - Gegler, Heinruch
IR  - Gegler H
FIR - Gekeler, Helmut
IR  - Gekeler H
FIR - Giese, Kerstin
IR  - Giese K
FIR - Gola, Gunstram
IR  - Gola G
FIR - Grad, Marc Oliver
IR  - Grad MO
FIR - Greifeneder, Herwig
IR  - Greifeneder H
FIR - Grun, Stefan
IR  - Grun S
FIR - Gruner, Ellen
IR  - Gruner E
FIR - Gut, Heinz
IR  - Gut H
FIR - Gutting, Matthias
IR  - Gutting M
FIR - Haerer, Winfried
IR  - Haerer W
FIR - Hagenow, Andreas
IR  - Hagenow A
FIR - Hahn, Rudiger
IR  - Hahn R
FIR - Hartmann, Susanne
IR  - Hartmann S
FIR - Haufe, Corina
IR  - Haufe C
FIR - Haufe, Stefan
IR  - Haufe S
FIR - Hechler, Rudiger
IR  - Hechler R
FIR - Heda, Barbara
IR  - Heda B
FIR - Hein, Konrad
IR  - Hein K
FIR - Herbst, Ingo
IR  - Herbst I
FIR - Herpolsheimer, Frank
IR  - Herpolsheimer F
FIR - Hess, Karl-Michael
IR  - Hess KM
FIR - Hillinger, Wolfgang
IR  - Hillinger W
FIR - Hintze, Rene
IR  - Hintze R
FIR - Holtz, Holger
IR  - Holtz H
FIR - Hudelmaier, Azra
IR  - Hudelmaier A
FIR - Hueck, Christian
IR  - Hueck C
FIR - Jaehn, Thomas
IR  - Jaehn T
FIR - Jonuleit, Cornelia
IR  - Jonuleit C
FIR - Kannenberg, Jorg
IR  - Kannenberg J
FIR - Kempf, Peter
IR  - Kempf P
FIR - Kendzia, Alexander
IR  - Kendzia A
FIR - Kiesel, Erhard
IR  - Kiesel E
FIR - Kleinbach, Klaus
IR  - Kleinbach K
FIR - Knapp, Markus
IR  - Knapp M
FIR - Knorpp, Rudolf
IR  - Knorpp R
FIR - Kobel, Michael
IR  - Kobel M
FIR - Konietzko, Agathe
IR  - Konietzko A
FIR - Kraiss, Martin
IR  - Kraiss M
FIR - Krause-Allmendinger, Helmut
IR  - Krause-Allmendinger H
FIR - Kuhlkamp, Volker
IR  - Kuhlkamp V
FIR - Kuhne, Ursula
IR  - Kuhne U
FIR - Kurth, Carsten
IR  - Kurth C
FIR - Laskos, Klaus
IR  - Laskos K
FIR - Lenz, Lutz
IR  - Lenz L
FIR - Loffler, Richard
IR  - Loffler R
FIR - Lokies, Jan
IR  - Lokies J
FIR - Loprich, Bruno
IR  - Loprich B
FIR - Lorenz, Lucian
IR  - Lorenz L
FIR - Lotsch, Manuela
IR  - Lotsch M
FIR - Mahler, Hans
IR  - Mahler H
FIR - Markert, Tilman
IR  - Markert T
FIR - Martens, Hellmut
IR  - Martens H
FIR - Mayer, Frank
IR  - Mayer F
FIR - Mayerheim, Sony
IR  - Mayerheim S
FIR - Mende, Marion
IR  - Mende M
FIR - Merz, Gerhard
IR  - Merz G
FIR - Metz, Werner
IR  - Metz W
FIR - Metzler, Jorg
IR  - Metzler J
FIR - Mies, Peter
IR  - Mies P
FIR - Moller, Christine
IR  - Moller C
FIR - Moller, Swetlana
IR  - Moller S
FIR - Morgan, Paul
IR  - Morgan P
FIR - Moser, Bernd
IR  - Moser B
FIR - Mulzer, Johanna
IR  - Mulzer J
FIR - Natour, Mohammed
IR  - Natour M
FIR - Neeb, Bernd
IR  - Neeb B
FIR - Niedrig, Kristina
IR  - Niedrig K
FIR - Nowzohour, Djafar
IR  - Nowzohour D
FIR - Oeder, Robert
IR  - Oeder R
FIR - Petcu, George
IR  - Petcu G
FIR - Pfeiffer, Wilhelm
IR  - Pfeiffer W
FIR - Pinkwart, Lutz-Ulrich
IR  - Pinkwart LU
FIR - Plappert, Bernhard
IR  - Plappert B
FIR - Pomiersky, Christian
IR  - Pomiersky C
FIR - Potsch, Thomas
IR  - Potsch T
FIR - Pricelius, Sabine
IR  - Pricelius S
FIR - Pulvermuller, Frank
IR  - Pulvermuller F
FIR - Putze, Kersten
IR  - Putze K
FIR - Raible, Rudolf
IR  - Raible R
FIR - Rathert, Bernhard
IR  - Rathert B
FIR - Reich, Christiane
IR  - Reich C
FIR - Rek, Birgit
IR  - Rek B
FIR - Ritter, Berthold
IR  - Ritter B
FIR - Roder, Frank
IR  - Roder F
FIR - Rommel, Theophil
IR  - Rommel T
FIR - Rosch, Dieter
IR  - Rosch D
FIR - Saurbier, Bernward
IR  - Saurbier B
FIR - Scheuermann, Oliver
IR  - Scheuermann O
FIR - Schiefer, Christina
IR  - Schiefer C
FIR - Schlick, Matthias
IR  - Schlick M
FIR - Schmitt, Frank
IR  - Schmitt F
FIR - Scholz, Harald
IR  - Scholz H
FIR - Scholz, Thomas
IR  - Scholz T
FIR - Schultze, Dietrich
IR  - Schultze D
FIR - Schumm, Wolfram
IR  - Schumm W
FIR - Schwehr, Udo
IR  - Schwehr U
FIR - Schwerecke, Anke
IR  - Schwerecke A
FIR - Seifart, Christoph
IR  - Seifart C
FIR - Seyfferth, Thomas
IR  - Seyfferth T
FIR - Sieroslawski, Ludwig
IR  - Sieroslawski L
FIR - Simon, Josef
IR  - Simon J
FIR - Sinn, Lutz
IR  - Sinn L
FIR - Sommerfeldt, Antje
IR  - Sommerfeldt A
FIR - Spangenberg, Birgit
IR  - Spangenberg B
FIR - Steffens, Cornelius
IR  - Steffens C
FIR - Stiller, Wolfgang
IR  - Stiller W
FIR - Strahle, Erwin
IR  - Strahle E
FIR - Szerdahelyi, Ulrike
IR  - Szerdahelyi U
FIR - Tamm, Angelika
IR  - Tamm A
FIR - Tardel, Johannes
IR  - Tardel J
FIR - Theiss, Alexander
IR  - Theiss A
FIR - Thriemer, Martin
IR  - Thriemer M
FIR - Tiede, Nikolaus
IR  - Tiede N
FIR - Toncar-Pflumm, Gisela
IR  - Toncar-Pflumm G
FIR - Toursarkissian, Nicole
IR  - Toursarkissian N
FIR - Treiber, Dietmar
IR  - Treiber D
FIR - Ulfert, Gunther
IR  - Ulfert G
FIR - Vogel-Suhrig, Christian
IR  - Vogel-Suhrig C
FIR - Vogt, Dierk-Christian
IR  - Vogt DC
FIR - Waldenmaier, Stefan
IR  - Waldenmaier S
FIR - Weber, Bernhard
IR  - Weber B
FIR - Wehr, Gabriele
IR  - Wehr G
FIR - Weiss, Gerhard
IR  - Weiss G
FIR - Wickenhauser, Bernhard
IR  - Wickenhauser B
FIR - Wild, Beate
IR  - Wild B
FIR - Willberg, Heinz-Andreas
IR  - Willberg HA
FIR - Zeddies, Heike
IR  - Zeddies H
FIR - Zeisler, Marianne
IR  - Zeisler M
FIR - Zieger, Stefan
IR  - Zieger S
FIR - Zietz, Hertraud
IR  - Zietz H
FIR - Blunert, Judith
IR  - Blunert J
FIR - Deckwart, Oliver
IR  - Deckwart O
FIR - Dubel, Hans-Peter
IR  - Dubel HP
FIR - Dziurla, Rene
IR  - Dziurla R
FIR - Fiss, Gunnar
IR  - Fiss G
FIR - Glass, Christine
IR  - Glass C
FIR - Heinold, Marrett
IR  - Heinold M
FIR - Kim, Simone
IR  - Kim S
FIR - Kohler, Friedrich
IR  - Kohler F
FIR - Kohler, Kerstin
IR  - Kohler K
FIR - Laurisch, Annett
IR  - Laurisch A
FIR - Lucke, Stephanie
IR  - Lucke S
FIR - Prescher, Sandra
IR  - Prescher S
FIR - Schannor, Brunhilde
IR  - Schannor B
FIR - Sellmer, Sibylle
IR  - Sellmer S
FIR - van der Spek, Daniel
IR  - van der Spek D
FIR - Winkler, Sebastian
IR  - Winkler S
FIR - Basrai, Daniel
IR  - Basrai D
FIR - Braun, Gregor
IR  - Braun G
FIR - Derin, Tuley
IR  - Derin T
FIR - Eckert, Joachim
IR  - Eckert J
FIR - Heinrich, Christian
IR  - Heinrich C
FIR - Honold, Marcus
IR  - Honold M
FIR - Kiebler, Reiner
IR  - Kiebler R
FIR - Lang, Alexandra
IR  - Lang A
FIR - Looser, Alexandra
IR  - Looser A
FIR - Maier, Cosima
IR  - Maier C
FIR - Muller-Dittner, Esther
IR  - Muller-Dittner E
FIR - Russner, Ilona
IR  - Russner I
FIR - Schieber, Michael
IR  - Schieber M
FIR - Sieprath, Sonja
IR  - Sieprath S
FIR - Victor, Achim
IR  - Victor A
EDAT- 2010/11/26 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - hfq199 [pii]
AID - 10.1093/eurjhf/hfq199 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Dec;12(12):1354-62. doi: 10.1093/eurjhf/hfq199.