PMID- 21103650
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20181201
IS  - 0932-0814 (Print)
IS  - 0932-0814 (Linking)
VI  - 24
IP  - 1
DP  - 2011
TI  - Evaluation of intra-articular and subcutaneous administration of meloxicam for 
      postoperative analgesia following stifle surgery in dogs.
PG  - 32-8
LID - 10.3415/VCOT-10-04-0059 [doi]
AB  - The objective of this study was to compare the efficacy of meloxicam when given 
      by intra-articular (IA) and subcutaneous (SC) routes of administration for 
      postoperative analgesia versus a placebo for dogs undergoing stifle surgery. 
      Twenty-five dogs with cranial cruciate ligament rupture (CCLR) were randomly 
      assigned to one of three treatment groups, each with nine dogs, before surgical 
      repair of twenty-seven stifles using a modified lateral retinacular imbrication 
      technique. Group 1 dogs received IA administration of meloxicam and SC placebo. 
      Group 2 dogs received IA placebo and SC meloxicam. Group 3 dogs received IA and 
      SC administration of placebo. Dogs were assessed for pain by blinded observers 
      using a visual analog scale (VAS), a numerical pain scoring system (NPS), and 
      measurement of pain threshold using an algometer applied to the affected stifle. 
      Assessments were made prior to pre-medication, postoperatively at the time of 
      extubation, and at 1, 2, 4, 6, 8, 10, 12, 16, 20, and 24 hours following 
      extubation. The results did not identify any significant effect of treatment 
      between groups on the VAS data, algometer readings, or NPS data. Significantly 
      increased VAS scores and decreased algometer readings were noted from 
      preoperative to postoperative times. No differences were noted in early 
      postoperative pain between dogs treated with IA meloxicam, SC meloxicam, or 
      placebo. While intra-articular non-steroidal anti- inflammatory drug 
      administration has shown efficacy in joint surgery for people, we did not find 
      any evidence to support its use in dogs undergoing repair of CCLR.
FAU - Moak, P
AU  - Moak P
AD  - Atlantic Veterinary College, Department of Companion Animals, University of 
      Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. 
      pmoak@upei.ca
FAU - Hosgood, G
AU  - Hosgood G
FAU - Rowe, E
AU  - Rowe E
FAU - Lemke, K A
AU  - Lemke KA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101119
PL  - Germany
TA  - Vet Comp Orthop Traumatol
JT  - Veterinary and comparative orthopaedics and traumatology : V.C.O.T
JID - 8906319
RN  - 0 (Analgesics)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Analgesics/administration & dosage/*therapeutic use
MH  - Animals
MH  - Dog Diseases/*drug therapy/etiology
MH  - Dogs
MH  - Injections, Intra-Articular
MH  - Injections, Subcutaneous
MH  - Meloxicam
MH  - Pain, Postoperative/drug therapy/*veterinary
MH  - Stifle/*surgery
MH  - Thiazines/administration & dosage/*therapeutic use
MH  - Thiazoles/administration & dosage/*therapeutic use
EDAT- 2010/11/26 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/04/10 00:00 [received]
PHST- 2010/07/24 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 10-04-0059 [pii]
AID - 10.3415/VCOT-10-04-0059 [doi]
PST - ppublish
SO  - Vet Comp Orthop Traumatol. 2011;24(1):32-8. doi: 10.3415/VCOT-10-04-0059. Epub 
      2010 Nov 19.