PMID- 21104643
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20170302
IS  - 0423-104X (Print)
IS  - 0423-104X (Linking)
VI  - 61
IP  - 6
DP  - 2010 Nov-Dec
TI  - Transforming growth factor beta (TGF-beta) levels in otherwise healthy subjects with 
      impaired glucose tolerance.
PG  - 691-4
AB  - INTRODUCTION: Serum transforming growth factor beta (TGF-beta) level is increased in 
      type-2 diabetes mellitus (T2DM) and certain diabetic complications are mediated 
      by this cytokine. Impaired glucose tolerance (IGT) is a prediabetic condition, 
      and confers a risk for the development of certain diabetes-specific 
      complications. However, no data is available regarding the alteration of TGF-beta in 
      IGT subjects. Therefore, we aimed to investigate TGF-beta levels in otherwise 
      healthy subjects with IGT. MATERIAL AND METHODS: Thirty IGT subjects and 30 
      subjects relatively matched for age, sex and body mass index with normal glucose 
      tolerance were enrolled. Subjects with overt diabetes, cardiovascular, renal or 
      inflammatory disease, or on any medication were excluded. Relevant laboratory 
      examinations were performed by routine methods. Assessment of TGF-beta was made by a 
      commercially available enzyme-linked immunosorbent assay kit. IGT and control 
      subjects were compared for their clinical and laboratory parameters. RESULTS: 
      Serum TGF-beta levels were found to be similar in IGT and normal glucose tolerance 
      subjects (p < 0.05). No statistically significant correlation was found between 
      TGF-beta and other laboratory parameters, either in IGT subjects or in the whole 
      study population. CONCLUSIONS: Serum TGF-beta is not elevated in otherwise healthy 
      subjects with IGT. The results of our study imply that the presence of IGT alone 
      is not sufficient to induce TGF-beta elevation; and for the alteration of TGF-beta, 
      worsening of metabolic risk factors may be required.
FAU - Genc, Halil
AU  - Genc H
AD  - Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, 
      Turkey.
FAU - Karadurmus, Nuri
AU  - Karadurmus N
FAU - Kisa, Ucler
AU  - Kisa U
FAU - Tapan, Serkan
AU  - Tapan S
FAU - Naharci, Ilkin
AU  - Naharci I
FAU - Sonmez, Alper
AU  - Sonmez A
FAU - Dogru, Teoman
AU  - Dogru T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Endokrynol Pol
JT  - Endokrynologia Polska
JID - 0370674
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Humans
MH  - Male
MH  - Prediabetic State/*blood
MH  - Transforming Growth Factor beta/*blood
EDAT- 2010/11/26 06:00
MHDA- 2011/05/13 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
PST - ppublish
SO  - Endokrynol Pol. 2010 Nov-Dec;61(6):691-4.