PMID- 21105847
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20190816
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 131
IP  - 2
DP  - 2011 Feb
TI  - Duffy antigen receptor for chemokines in laryngeal squamous cell carcinoma as a 
      negative regulator.
PG  - 197-203
LID - 10.3109/00016489.2010.516012 [doi]
AB  - CONCLUSION: Duffy antigen receptor for chemokines (DARC), as a negative 
      regulator, could attenuate the potential growth and metastasis of laryngeal 
      squamous cell carcinoma (LSCC); hence it could be considered as a basis for a new 
      prognostic aid and molecular therapeutic target in treating LSCC. OBJECTIVES: To 
      analyze the role of DARC in LSCC progression using LSCC clinical samples. 
      METHODS: A total of 65 LSCC tissues were examined immunohistochemically for DARC 
      protein expression. The microvessel density (MVD) was determined by the 
      endothelial cells immunostained using anti-CD34 antibody. RESULTS: It was found 
      that DARC was expressed in the LSCC samples, with a high expression in 32 of our 
      cases (49.2%), and in lymph node-negative and -positive groups of 24 (72.7%) and 
      8 cases (25%), respectively (p < 0.01). MVD was (24.75 +/- 5.45)/High power field 
      (HP) and (32.58 +/- 5.23)/HP in the cases with high and low expression of DARC, 
      respectively (p < 0.01). More importantly, the DARC expression presented a strong 
      negative correlation with nodal metastasis, with pTNM stage, and with recurrence, 
      and the cases with a high DARC expression indicated a higher survival rate. In 
      addition, the multivariate analysis showed that the DARC expression was an 
      independent prognostic factor (p = 0.032; hazard ratio, 21.476; 95% confidence 
      interval, 1.297-355.68).
FAU - Sun, Guohua
AU  - Sun G
AD  - Department of Head & Neck Surgery, Fudan University Shanghai Cancer Center and 
      Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      China.
FAU - Wang, Yu
AU  - Wang Y
FAU - Zhu, Yongxue
AU  - Zhu Y
FAU - Huang, Caiping
AU  - Huang C
FAU - Ji, Qinghai
AU  - Ji Q
LA  - eng
PT  - Journal Article
DEP - 20101125
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (ACKR1 protein, human)
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD34/metabolism
MH  - Biomarkers/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cohort Studies
MH  - Duffy Blood-Group System/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Receptors, Cell Surface/*metabolism
EDAT- 2010/11/26 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.3109/00016489.2010.516012 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2011 Feb;131(2):197-203. doi: 10.3109/00016489.2010.516012. 
      Epub 2010 Nov 25.