PMID- 21107733
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 38
IP  - 4
DP  - 2011 Apr
TI  - Killer cell immunoglobulin-like receptor gene diversity in the Saudi population.
PG  - 2603-10
LID - 10.1007/s11033-010-0401-y [doi]
AB  - Killer cell immunoglobulin-like receptors (KIRs) influence the outcome of 
      haematopoetic stem cell transplantation by modulating the cytotoxic ability of 
      natural killer (NK) cells and a subset of T cells. KIRs are also highly 
      polymorphic and could therefore be good population genetic markers, much like 
      their human leukocyte antigen (HLA) ligands. This study represents the first 
      report on distribution of 16 KIR genes in 162 unrelated healthy Saudi 
      individuals. All the 16 KIR genes were observed in the studied population and the 
      four framework genes (KIR2DL4, 3DL2, 3DL3 and 3DP1) were present in all 
      individuals. Forty- one distinct KIR profiles were expressed in our population, 
      11 of which had not been previously described in other populations including the 
      Middle Eastern population. AA1, the most common genotypic profile was observed at 
      a frequency of 26.5%. The group A haplotype was more frequent (53%) in the Saudi 
      population compared to the group B haplotype (47%). The pattern of the inhibitory 
      KIR/HLA ligands were also analyzed and 52.3% of the Saudi population was found to 
      express two pairs of the inhibitory KIR/HLA-C. The KIR gene frequencies suggests 
      that the Saudi population shares common general features with the Middle Eastern 
      and other populations, but still has its own unique frequencies of several KIR 
      loci.
FAU - Gaafar, Ameera
AU  - Gaafar A
AD  - Histocompatibility and Immunogenetics, Stem Cell Therapy Program, King Faisal 
      Specialist Hospital and Research Centre, PO Box 3354, Riyadh, 11211, Saudi 
      Arabia.
FAU - Sheereen, Atia
AU  - Sheereen A
FAU - Iqneibi, Alia
AU  - Iqneibi A
FAU - Mohamed, Gamal
AU  - Mohamed G
FAU - Al Sulaiman, Abdullah
AU  - Al Sulaiman A
FAU - Turpeinen, Hannu
AU  - Turpeinen H
FAU - Al Hussein, Khalid
AU  - Al Hussein K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101124
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (HLA-C Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Female
MH  - *Genetic Variation
MH  - Genotype
MH  - HLA-C Antigens/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Male
MH  - *Phenotype
MH  - Receptors, KIR/*genetics
MH  - Saudi Arabia
EDAT- 2010/11/26 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/03/08 00:00 [received]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1007/s11033-010-0401-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2011 Apr;38(4):2603-10. doi: 10.1007/s11033-010-0401-y. Epub 2010 
      Nov 24.