PMID- 21107986
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 26
IP  - 2
DP  - 2011 Feb
TI  - Urinary transforming growth factor beta-1 as a marker of renal dysfunction in 
      sickle cell disease.
PG  - 275-80
LID - 10.1007/s00467-010-1677-9 [doi]
AB  - Renal dysfunction affects 5-18% of patients with sickle cell disease (SCD). To 
      date, no studies have described urinary levels of transforming growth factor beta-1 
      (TGF-beta1), a marker of fibrosis, and neutrophil gelatinase-associated lipocalin 
      (NGAL), a marker of acute/chronic kidney disease, as biomarkers in identifying 
      patients at risk of developing renal disease in SCD. We hypothesized that SCD 
      subjects will have increased urinary excretion of TGF-beta1 and NGAL compared with 
      healthy controls (CTR). We examined 51 SCD subjects: 42 HbSS, 8 HbSC, and 1 HbSD. 
      Sixteen out of 42 patients with HbSS were on hydroxyurea (HU). Urinary excretion 
      of TGF-beta1 was 26.4 +/- 1.5 pg/mgCr in SCD subjects vs 15.0 +/- 2.4 pg/mgCr in CTR 
      (p<0.00001). SCD patients with hemoglobin < 9 g/dl had higher urinary TGF-beta1 than 
      patients with milder anemia (p=0.002). Urinary TGF-beta1 trended lower in HbSS 
      patients treated with HU (23.61 +/- 2.6 pg/mgCr), vs patients not on HU (27.69 +/- 
      1.8 pg/mgCr; p=0.055). There was no correlation between urinary TGF-beta1 and 
      microalbuminuria or estimated glomerular function. There was no difference in 
      urinary NGAL in SCD patients vs CTR. We suggest that urinary TGF-beta1 may serve as 
      a marker of early renal injury in SCD.
FAU - Mohtat, Davoud
AU  - Mohtat D
AD  - Department of Pediatric Nephrology, Albert Einstein College of Medicine, 
      Children's Hospital at Montefiore, 111 East 210th Street, Bronx, NY 10467, USA.
FAU - Thomas, Rosemary
AU  - Thomas R
FAU - Du, Zangfang
AU  - Du Z
FAU - Boakye, Yaa
AU  - Boakye Y
FAU - Moulton, Thomas
AU  - Moulton T
FAU - Driscoll, Catherine
AU  - Driscoll C
FAU - Woroniecki, Robert
AU  - Woroniecki R
LA  - eng
GR  - DK007110-34/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101125
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Acute-Phase Proteins/*urine
MH  - Adolescent
MH  - Age Factors
MH  - Albuminuria/metabolism
MH  - Anemia, Sickle Cell/*complications
MH  - Biomarkers/urine
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney Diseases/*diagnosis/etiology/*urine
MH  - Lipocalin-2
MH  - Lipocalins/*urine
MH  - Male
MH  - Proto-Oncogene Proteins/*urine
MH  - Transforming Growth Factor beta/*urine
MH  - Young Adult
EDAT- 2010/11/26 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/06/28 00:00 [received]
PHST- 2010/09/17 00:00 [accepted]
PHST- 2010/09/14 00:00 [revised]
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s00467-010-1677-9 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2011 Feb;26(2):275-80. doi: 10.1007/s00467-010-1677-9. Epub 2010 
      Nov 25.