PMID- 21107991
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20221207
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Jun
TI  - Contribution of an adenine to guanine single nucleotide polymorphism of the 
      matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of 
      anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared 
      epitope-negative rheumatoid arthritis.
PG  - 240-3
LID - 10.1007/s10165-010-0375-6 [doi]
AB  - We examined whether matrix metalloproteinase-13 (MMP-13) contributes to disease 
      susceptibility or severity of rheumatoid arthritis (RA). Eighty-seven patients 
      with RA whose disease duration was <2 years and 71 healthy controls were enrolled 
      in the study. Adenine (A) to guanine (G) single nucleotide polymorphism (SNP) of 
      the -77 MMP-13 promoter region in RA and healthy controls was determined by 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 
      technique. Human leukocyte antigen (HLA)-DRB1 genotyping was also performed using 
      the same populations. Anticyclic citrullinated peptide (anti-CCP) antibodies from 
      RA patients at entry were studied, and their relationships were examined. The 
      genotype and allele frequency of SNP of MMP-13 at -77 did not differ between RA 
      patients and healthy controls. We focused on the RA patients who were negative 
      for HLA-DRB1*shared epitope (SE) alleles and found that the seropositivity of 
      anti-CCP antibodies with a titer >25 U/ml was high in the A/A genotype compared 
      with the G/G genotype. The same characteristic was also found in HLA-DRB1*0405 
      allele-negative patients. Our data suggest that SNP of the -77 MMP-13 promoter 
      region acts as a surrogate marker of anti-CCP antibody production in HLA-DRB1*SE 
      allele-negative RA patients, which may reflect RA severity.
FAU - Iwamoto, Naoki
AU  - Iwamoto N
AD  - Unit of Translational Medicine, Department of Immunology and Rheumatology, 
      Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan. naoki_iwa@hotmail.com
FAU - Kawakami, Atsushi
AU  - Kawakami A
FAU - Arima, Kazuhiko
AU  - Arima K
FAU - Tamai, Mami
AU  - Tamai M
FAU - Nakamura, Hideki
AU  - Nakamura H
FAU - Kawashiri, Shin-ya
AU  - Kawashiri SY
FAU - Kita, Junko
AU  - Kita J
FAU - Okada, Akitomo
AU  - Okada A
FAU - Koga, Tomohiro
AU  - Koga T
FAU - Kamachi, Makoto
AU  - Kamachi M
FAU - Yamasaki, Satoshi
AU  - Yamasaki S
FAU - Ichinose, Kunihiro
AU  - Ichinose K
FAU - Ida, Hiroaki
AU  - Ida H
FAU - Origuchi, Tomoki
AU  - Origuchi T
FAU - Eguchi, Katsumi
AU  - Eguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101126
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Autoantibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
RN  - EC 3.4.24.- (MMP13 protein, human)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/ethnology/*genetics/*immunology
MH  - Asian People/genetics/statistics & numerical data
MH  - Autoantibodies/*genetics/immunology
MH  - Epitopes/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease/ethnology/genetics
MH  - Genotype
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Matrix Metalloproteinase 13/*genetics/immunology
MH  - Middle Aged
MH  - Peptides, Cyclic/*immunology
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2010/11/26 06:00
MHDA- 2011/10/12 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/10/20 00:00 [accepted]
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - 10.1007/s10165-010-0375-6 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2011 Jun;21(3):240-3. doi: 10.1007/s10165-010-0375-6. Epub 2010 
      Nov 26.