PMID- 21108691
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20171116
IS  - 1740-0929 (Electronic)
IS  - 1344-3941 (Linking)
VI  - 81
IP  - 6
DP  - 2010 Dec
TI  - Anti-allergic effects of Lactobacillus crispatus KT-11 strain on 
      ovalbumin-sensitized BALB/c mice.
PG  - 699-705
LID - 10.1111/j.1740-0929.2010.00795.x [doi]
AB  - In this study, we investigated the effects of oral ingestion of Lactobacillus 
      crispatus KT-11 strain (KT-11) on the immune response in an allergic rhinitis 
      mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice 
      that were administered a KT-11-supplemented diet was significantly lower than 
      that in mice administered a KT-11-free diet (control diet) at age 11 weeks. We 
      found that serum OVA-specific immunoglobulin E (IgE) levels and total number of 
      interleukin (IL)-4(+) CD4(+) spleen cells in mice that were administered a 
      KT-11-supplemented diet were significantly lower than in mice administered a 
      control diet. The ratio of spleen interferon-gamma(+) CD4(+) /IL-4(+) CD4(+) cells 
      was higher in the mice administered the KT-11-supplemented diet compared to that 
      in mice administered the control or L. rhamnosus GG-supplemented diet. In 
      contrast, the number of CD11b(+) CD80(+) and FcepsilonRIalpha(+) CD117(+) cells was 
      significantly lower in mice administered the KT-11-supplemented diet. These 
      results suggested that KT-11 reduced OVA-induced allergic symptoms in BALB/c mice 
      via the adjustment of the T helper type 1/T helper type 2 balance, and a decrease 
      in the number of antigen-presenting cells and high affinity IgE receptor-positive 
      mast cells.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 Japanese Society of Animal 
      Science.
FAU - Tobita, Keisuke
AU  - Tobita K
AD  - Shinshu University, Kawasaki, Japan.
FAU - Yanaka, Hiroyuki
AU  - Yanaka H
FAU - Otani, Hajime
AU  - Otani H
LA  - eng
PT  - Journal Article
DEP - 20101007
PL  - Australia
TA  - Anim Sci J
JT  - Animal science journal = Nihon chikusan Gakkaiho
JID - 100956805
RN  - 0 (CD4 Antigens)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Animal Feed
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - CD4 Antigens
MH  - Disease Models, Animal
MH  - Immunoglobulin E/blood
MH  - Interleukin-4
MH  - *Lactobacillus
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/*immunology
MH  - Probiotics/administration & dosage/*pharmacology/*therapeutic use
MH  - Rhinitis, Allergic, Perennial/*immunology/*therapy
MH  - Spleen/cytology/immunology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2010/11/27 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1111/j.1740-0929.2010.00795.x [doi]
PST - ppublish
SO  - Anim Sci J. 2010 Dec;81(6):699-705. doi: 10.1111/j.1740-0929.2010.00795.x. Epub 
      2010 Oct 7.