PMID- 21111832
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20110131
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Mar 1
TI  - Associations and dissociations between default and self-reference networks in the 
      human brain.
PG  - 225-32
LID - 10.1016/j.neuroimage.2010.11.048 [doi]
AB  - Neuroimaging has revealed consistent activations in medial prefrontal cortex 
      (MPFC) and posterior cingulate cortex (PCC) extending to precuneus both during 
      explicit self-reference tasks and during rest, a period during which some form of 
      self-reference is assumed to occur in the default mode of brain function. The 
      similarity between these two patterns of midline cortical activation may reflect 
      a common neural system for explicit and default-mode self-reference, but there is 
      little direct evidence about the similarities and differences between the neural 
      systems that mediate explicit self-reference versus default-mode self-reference 
      during rest. In two experiments, we compared directly the brain regions activated 
      by explicit self-reference during judgments about trait adjectives and by rest 
      conditions relative to a semantic task without self-reference. Explicit 
      self-reference preferentially engaged dorsal MPFC, rest preferentially engaged 
      precuneus, and both self-reference and rest commonly engaged ventral MPFC and 
      PCC. These findings indicate that there are both associations (shared components) 
      and dissociations between the neural systems underlying explicit self-reference 
      and the default mode of brain function.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Whitfield-Gabrieli, Susan
AU  - Whitfield-Gabrieli S
AD  - Massachusetts Institute of Technology, Department of Brain and Cognitive 
      Sciences, Harvard-MIT Division of Health Sciences and Technology, and Poitras 
      Center for Affective Disorders Research, Cambridge, MA 02139, USA swg@mit.edu
FAU - Moran, Joseph M
AU  - Moran JM
FAU - Nieto-Castanon, Alfonso
AU  - Nieto-Castanon A
FAU - Triantafyllou, Christina
AU  - Triantafyllou C
FAU - Saxe, Rebecca
AU  - Saxe R
FAU - Gabrieli, John D E
AU  - Gabrieli JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101125
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Cognition/*physiology
MH  - *Ego
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Nerve Net/*physiology
MH  - *Self Concept
EDAT- 2010/11/30 06:00
MHDA- 2011/05/14 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/11/11 00:00 [revised]
PHST- 2010/11/12 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - S1053-8119(10)01526-0 [pii]
AID - 10.1016/j.neuroimage.2010.11.048 [doi]
PST - ppublish
SO  - Neuroimage. 2011 Mar 1;55(1):225-32. doi: 10.1016/j.neuroimage.2010.11.048. Epub 
      2010 Nov 25.