PMID- 21111984
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20151119
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 16
IP  - 12
DP  - 2010 Dec
TI  - Serum levels of high-sensitivity troponin T: a novel marker for cardiac 
      remodeling in hypertrophic cardiomyopathy.
PG  - 950-6
LID - 10.1016/j.cardfail.2010.07.245 [doi]
AB  - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by inappropriate 
      hypertrophy, small-vessel coronary artery disease, myocyte disarray, and 
      increased interstitial fibrosis. High-sensitivity troponin T (hs-TnT) could be a 
      reliable indicator of myocardial remodeling, a proposed prognostic marker in HCM. 
      Therefore we hypothesized that increased hs-TnT levels are related to different 
      variables associated with myocardial remodeling, such as the presence of fibrosis 
      assessed with cardiac magnetic resonance imaging (MRI). METHODS AND RESULTS: We 
      included 95 hemodynamically stable HCM patients, 72 male, aged 45.7 +/- 14.2 years, 
      and 45 healthy control subjects with similar age and gender. A complete history 
      and clinical examination was performed, including 12-lead electrocardiogram 
      (ECG), echocardiography, 24-hour ECG-Holter monitoring, symptom-limited treadmill 
      exercise test, and late gadolinium enhancement in cardiac MRI. Risk factors for 
      sudden death were evaluated. A blinded cardiac MRI was performed with late 
      gadolinium enhancement study. Serum hs-TnT levels were assayed. A high proportion 
      (42%) of hemodynamically stable patients studied showed increased levels of 
      hs-TnT. The hs-TnT levels were raised in patients with severe dyspnea: New York 
      Heart Association (NYHA) functional class >/=3 (P = .020), outflow obstruction (P = 
      .013), systolic dysfunction (P = .037), abnormal blood pressure response (P = 
      .036), and presence of gadolinium enhancement (P = .021). The hs-TnT levels 
      correlated positively with the maximum left ventricular wall thickness (r = 0.47; 
      P < .001), left atrial diameter (r = 0.36, P = .014), and outflow gradient (r = 
      0.28; P = .008). CONCLUSIONS: A high proportion of hemodynamically stable 
      patients show increased levels of hs-TnT. We observed that raised hs-TnT serum 
      levels are associated with different conditions related to the severity of the 
      disease.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Moreno, Victoria
AU  - Moreno V
AD  - Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, 
      Spain.
FAU - Hernandez-Romero, Diana
AU  - Hernandez-Romero D
FAU - Vilchez, Juan Antonio
AU  - Vilchez JA
FAU - Garcia-Honrubia, Antonio
AU  - Garcia-Honrubia A
FAU - Cambronero, Francisco
AU  - Cambronero F
FAU - Casas, Teresa
AU  - Casas T
FAU - Gonzalez, Josefa
AU  - Gonzalez J
FAU - Martinez, Pedro
AU  - Martinez P
FAU - Climent, Vicente
AU  - Climent V
FAU - de la Morena, Gonzalo
AU  - de la Morena G
FAU - Valdes, Mariano
AU  - Valdes M
FAU - Marin, Francisco
AU  - Marin F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Hypertrophic/*blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Troponin T/*blood
EDAT- 2010/11/30 06:00
MHDA- 2011/10/12 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/06/28 00:00 [revised]
PHST- 2010/07/02 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - S1071-9164(10)00960-7 [pii]
AID - 10.1016/j.cardfail.2010.07.245 [doi]
PST - ppublish
SO  - J Card Fail. 2010 Dec;16(12):950-6. doi: 10.1016/j.cardfail.2010.07.245.