PMID- 21112374
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20221207
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 332
IP  - 1-2
DP  - 2011 Jan 30
TI  - AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA 
      and could be a risk factor for type 2 diabetes in a Chinese population.
PG  - 301-5
LID - 10.1016/j.mce.2010.11.021 [doi]
AB  - The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. 
      Because oxidative stress may contribute to increased diabetes risk, the common 
      variant of the MUTYH gene (AluYb8MUTYH) was investigated for its possible role in 
      type 2 diabetes mellitus (T2DM). A total of 565 T2DM patients and 565 healthy 
      subjects from China were enrolled in a case-control study. The distribution of 
      AluYb8MUTYH differed in diabetic patients from controls, with a moderately 
      increased percentage of the mutant allele (P) (44.7% versus 40.3%, P = 0.033, OR 
      = 1.199). However, this distribution was similar between the diabetic early-onset 
      and late-onset subgroups. Another 66 T2DM patients were further evaluated for 
      8-hydroxy-2'deoxyguanosine (8-OHdG) levels in leukocytic DNA. The average value 
      of 8-OHdG/10(6) dG was 10.4 in patients with the wild-type genotype, 15.9 in 
      heterozygotes, and 22.3 in homozygotes with the variation (P < 0.001, compared 
      with the wild-type). Therefore, the AluYb8MUTYH polymorphism could be a novel 
      genetic risk factor for T2DM, and accumulated 8-OHdG could contribute to this 
      disease.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Chen, Huimei
AU  - Chen H
AD  - Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, 
      China; Jiangsu Key Lab of Molecular Medicine, Nanjing University, Nanjing, China.
FAU - Sun, Caixia
AU  - Sun C
FAU - Guo, Wenwen
AU  - Guo W
FAU - Meng, Ran
AU  - Meng R
FAU - Du, Hong
AU  - Du H
FAU - Qi, Qiufeng
AU  - Qi Q
FAU - Gu, Xin
AU  - Gu X
FAU - Li, Lirong
AU  - Li L
FAU - Zhang, Kui
AU  - Zhang K
FAU - Zhu, Dalong
AU  - Zhu D
FAU - Wang, Yaping
AU  - Wang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101126
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - 9007-49-2 (DNA)
RN  - EC 3.2.2.- (DNA Glycosylases)
RN  - EC 3.2.2.- (mutY adenine glycosylase)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - DNA/*genetics
MH  - DNA Glycosylases/*genetics
MH  - Deoxyguanosine/*analogs & derivatives/metabolism
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Leukocytes/physiology
MH  - Male
MH  - Middle Aged
MH  - *Mutagenesis, Insertional
MH  - Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2010/11/30 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2010/11/04 00:00 [revised]
PHST- 2010/11/19 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - S0303-7207(10)00549-6 [pii]
AID - 10.1016/j.mce.2010.11.021 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2011 Jan 30;332(1-2):301-5. doi: 10.1016/j.mce.2010.11.021. 
      Epub 2010 Nov 26.