PMID- 21112921
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20171116
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Apr
TI  - Effects of a therapeutic lifestyle modification program on inflammatory 
      chemokines and insulin resistance in subjects with metabolic syndrome.
PG  - 182-8
LID - 10.1177/1099800410383305 [doi]
AB  - BACKGROUND: Although therapeutic lifestyle modification (TLM) effectively 
      improves the values of diagnostic biomarkers of metabolic syndrome, less is known 
      about its effects on inflammatory chemokines and insulin resistance (IR) in 
      patients with this syndrome. Objectives. To examine the effects of a short-term 
      TLM program on inflammatory chemokines (monocyte chemoattractant protein-1 
      [MCP-1], retinol binding protein-4 [RBP-4]) and IR in subjects with metabolic 
      syndrome. METHOD: Twenty-nine women (aged 66.5 +/- 9.5 years) with metabolic 
      syndrome were randomly assigned to the TLM intervention group (n = 16) or control 
      group (n = 13). The TLM intervention group was provided with 4 weeks of health 
      screening, education, exercise, diet, and counseling. Participants in the control 
      group were instructed to maintain their usual lifestyle behavior. Outcome 
      variables measured included MCP-1, RBP-4, fasting glucose, fasting insulin, and 
      homeostasis model assessment (HOMA). An intention-to-treat strategy was not 
      followed, and the final number of subjects in the analysis was 22 (14 in the TLM 
      group and 8 in the control group). RESULTS: After a 4-week TLM program, MCP-1, 
      fasting insulin, and HOMA were significantly decreased in the TLM group compared 
      to those in the control group (all p < .05). CONCLUSIONS: We conclude that a 
      short-term TLM program could be effective for improving inflammatory state and 
      IR, which are significant preceding biomarkers for cardiovascular complications 
      in subjects with metabolic syndrome.
FAU - Oh, Eui Geum
AU  - Oh EG
AD  - College of Nursing, Nursing Policy and Research Institution, Yonsei University, 
      Seoul, South Korea.
FAU - Chu, Sang Hui
AU  - Chu SH
FAU - Bang, So Youn
AU  - Bang SY
FAU - Lee, Mi Kyung
AU  - Lee MK
FAU - Kim, Soo Hyun
AU  - Kim SH
FAU - Hyun, Sa Saeng
AU  - Hyun SS
FAU - Jeon, Justin Y
AU  - Jeon JY
FAU - Im, Jee Aee
AU  - Im JA
FAU - Lee, Jung Eun
AU  - Lee JE
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101126
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Chemokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
EIN - Biol Res Nurs. 2012 Jul;14(3):302. Jeon, Yong Kwan [corrected to Jeon, Justin Y]
MH  - Aged
MH  - Chemokines/*blood
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - *Insulin Resistance
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - *Risk Reduction Behavior
EDAT- 2010/11/30 06:00
MHDA- 2011/07/13 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 1099800410383305 [pii]
AID - 10.1177/1099800410383305 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2011 Apr;13(2):182-8. doi: 10.1177/1099800410383305. Epub 2010 Nov 
      26.