PMID- 21113741
OWN - NLM
STAT- MEDLINE
DCOM- 20111010
LR  - 20220311
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
VI  - 59
IP  - 3
DP  - 2011 Apr
TI  - The association of the metalloproteinase-3 gene promoter polymorphisms and the 
      middle cerebral artery stenosis.
PG  - 185-9
LID - 10.1007/s12013-010-9131-y [doi]
AB  - To investigate the association of single nucleotide polymorphism in the matrix 
      metalloproteinase-3 (MMP3) gene promoter with the susceptibility to the middle 
      cerebral artery stenosis. A case-control study was performed by determining the 
      genotype of MMP3 gene promoter region using polymerase chain reaction-restriction 
      fragment length polymorphism in 119 patients with middle cerebral artery stenosis 
      documented by transcranial Doppler compared to 92 control patients. The 
      frequencies of 5A and 6A alleles in MMP3 promoter region were 16.0 and 84.0% 
      respectively in case group compared to 15.8 and 84.2% in control group with no 
      significant difference between the two groups (P > 0.05). No significant 
      difference was also observed in the distribution of genotypes 5A/5A,5A/6A, and 
      6A/6A between middle cerebral artery stenosis and control groups. Compared to 
      5A/5A + 5A/6A genotypes,the 6A/6A genotype did not significantly modify the risk 
      of developing the middle cerebral artery stenosis. The MMP3-1171 dupA promoter 
      polymorphisms are not valuable markers of susceptibility of the middle cerebral 
      artery stenosis in this sample of population studied.
FAU - Fu, Chunli
AU  - Fu C
AD  - Department of Neurology, The First Hospital of Jilin University, 77 Xinmin 
      street, Changchun, 130021, Jilin province, China.
FAU - Xing, Yingqi
AU  - Xing Y
FAU - Song, Xiaonan
AU  - Song X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Alleles
MH  - Carotid Stenosis/*genetics/pathology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Middle Cerebral Artery/*pathology
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2010/11/30 06:00
MHDA- 2011/10/11 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/10/11 06:00 [medline]
AID - 10.1007/s12013-010-9131-y [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2011 Apr;59(3):185-9. doi: 10.1007/s12013-010-9131-y.