PMID- 21114970
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20110110
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 412
IP  - 5-6
DP  - 2011 Feb 20
TI  - Monocyte chemoattractant protein 1-2518 A/G polymorphism and susceptibility to 
      type 2 diabetes in a Chinese population.
PG  - 466-9
LID - 10.1016/j.cca.2010.11.030 [doi]
AB  - BACKGROUND: Hyperglycemia could accelerate monocyte chemoattractant protein 1 
      (MCP-1) production in monocytes and vascular endothelial cells. Recently, a 
      genetic polymorphism (-2518 A/G) located in MCP-1 gene promoter has been found 
      that could influence the expression of MCP-1. A large cohort study of Caucasians 
      reported that MCP-1 G-2518 gene variant was negatively correlated with the 
      prevalence of insulin resistance and type 2 diabetes. However, it is unclear 
      whether this polymorphism is associated with type 2 diabetes in Han Chinese. 
      METHODS: We conducted a population-based case-control study of 416 type 2 
      diabetes cases and 416 controls. RESULTS: Compared with the wild genotype AA, 
      MCP-1 G-2518 gene variant could significantly decrease the prevalence of type 2 
      diabetes in Han Chinese (adjusted OR=0.49, 95% CI 0.32-0.77, P<0.0001). The 
      results of stratified analyses indicated that a decreased risk of type 2 diabetes 
      related with variant genotypes was evident in younger participants (age </=50) 
      (adjusted OR=0.35, 95% CI 0.20-0.61, P<0.0001), and similar results were observed 
      in males (adjusted OR=0.37, 95% CI 0.21-0.66, P=0.001) and urban participants 
      (adjusted OR=0.35, 95% CI 0.21-0.58, P<0.0001). In addition, a statistically 
      significant difference was observed between MCP-1-2518 A/G polymorphism and waist 
      to hip ratio. CONCLUSIONS: Our present pilot study indicated that MCP-1 G-2518 
      gene variant could significantly decrease the risk of type 2 diabetes in a 
      Chinese population.
CI  - Copyright A(c) 2010 Elsevier B.V. All rights reserved.
FAU - Jing, Yali
AU  - Jing Y
AD  - Department of Endocrinology, Affiliated Drum Tower Hospital, Medical College of 
      Nanjing University, Jiangsu Province, China.
FAU - Zhu, Dalong
AU  - Zhu D
FAU - Bi, Yan
AU  - Bi Y
FAU - Yang, Donghui
AU  - Yang D
FAU - Hu, Yun
AU  - Hu Y
FAU - Shen, Shanmei
AU  - Shen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101127
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
EDAT- 2010/12/01 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/07/04 00:00 [received]
PHST- 2010/11/21 00:00 [revised]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - S0009-8981(10)00715-1 [pii]
AID - 10.1016/j.cca.2010.11.030 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2011 Feb 20;412(5-6):466-9. doi: 10.1016/j.cca.2010.11.030. Epub 
      2010 Nov 27.