PMID- 21117246
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20220408
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 16
IP  - 12
DP  - 2010 Dec
TI  - Six-minute walk distance predicts mortality in liver transplant candidates.
PG  - 1373-8
LID - 10.1002/lt.22167 [doi]
AB  - The 6-minute walk distance (6MWD) is a simple test measuring global physical 
      function. It is commonly used to predict mortality in patients with cardiac and 
      pulmonary diseases, but it is also useful in assessing the functional status of 
      patients with a variety of other medical conditions. We sought to determine (1) 
      the characteristics of the 6MWD in patients listed for liver transplantation 
      (LT), (2) the existence of a relationship between the 6MWD and the quality of 
      life, and (3) the relationship between the 6MWD and survival in LT candidates. 
      The 6MWD was prospectively measured in all patients listed for LT. The 6MWD was 
      determined when the listed Model for End-Stage Liver Disease (MELD) score was >/= 
      15. Patients were followed until LT, death, removal from the wait list, or the 
      end of the study period. Quality of life was assessed with the Short Form 36 
      (SF-36). In 121 patients, the mean 6MWD was 369 +/- 122 m; it was not related to 
      age, height, weight, body mass index, albumin level, or etiology of liver disease 
      and showed a moderate correlation with the physical component score (PCS) on the 
      SF-36 (r = 0.4) and a moderate inverse correlation with the native MELD score (r 
      = -0.61). In an unadjusted analysis, a high native MELD score, a low 6MWD, and a 
      low PCS were associated with mortality, with only the 6MWD retaining significance 
      after adjustment for covariates. Each 100-m increase in the 6MWD was 
      significantly associated with increased survival (hazard ratio = 0.48, P = 
      0.0001), with 6MWD < 250 m being associated with an increased risk of death (P = 
      0.0001). In conclusion, the 6MWD is significantly reduced in patients awaiting LT 
      and is inversely correlated with the native MELD score. A pretransplant 6MWD < 
      250 m is a risk for death on the wait list.
CI  - Copyright (c) 2010 American Association for the Study of Liver Diseases.
FAU - Carey, Elizabeth J
AU  - Carey EJ
AD  - Divisions of Hepatology and Gastroenterology, Mayo Clinic Arizona, Phoenix, AZ 
      85054, USA. carey.elizabeth@mayo.edu
FAU - Steidley, D Eric
AU  - Steidley DE
FAU - Aqel, Bashar A
AU  - Aqel BA
FAU - Byrne, Thomas J
AU  - Byrne TJ
FAU - Mekeel, Kristin L
AU  - Mekeel KL
FAU - Rakela, Jorge
AU  - Rakela J
FAU - Vargas, Hugo E
AU  - Vargas HE
FAU - Douglas, David D
AU  - Douglas DD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Liver Diseases/*mortality/surgery
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Physical Endurance/*physiology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Time Factors
MH  - Waiting Lists
MH  - Walking/*physiology
EDAT- 2010/12/01 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1002/lt.22167 [doi]
PST - ppublish
SO  - Liver Transpl. 2010 Dec;16(12):1373-8. doi: 10.1002/lt.22167.