PMID- 21118724
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20220409
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Mar 1
TI  - Frequency-dependent changes in the amplitude of low-frequency fluctuations in 
      amnestic mild cognitive impairment: a resting-state fMRI study.
PG  - 287-95
LID - 10.1016/j.neuroimage.2010.11.059 [doi]
AB  - Here we utilized resting-state functional magnetic resonance imaging (R-fMRI) to 
      measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF 
      (fALFF) in 24 patients with amnestic mild cognitive impairment (aMCI) and 24 age- 
      and sex-matched healthy controls. Two different frequency bands (slow-5: 
      0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed. We showed that there were 
      widespread differences in ALFF/fALFF between the two bands in many brain regions, 
      predominantly including the medial prefrontal cortex (MPFC), posterior cingulate 
      cortex/precuneus (PCC/PCu), basal ganglia, and hippocampus/parahippocampal gyrus 
      (PHG). Compared to controls, the aMCI patients had decreased ALFF/fALFF values in 
      the PCC/PCu, MPFC, hippocampus/PHG, basal ganglia, and prefrontal regions, and 
      increased ALFF/fALFF values mainly in several occipital and temporal regions. 
      Specifically, we observed that the ALFF/fALFF abnormalities in the PCC/PCu, PHG, 
      and several occipital regions were greater in the slow-5 band than in the slow-4 
      band. Finally, our results of functional analysis were not significantly 
      influenced by the gray matter loss in the MCI patients, suggesting that the 
      results reflect functional differences between groups. Together, our data suggest 
      that aMCI patients have widespread abnormalities in intrinsic brain activity, and 
      the abnormalities depend on the studied frequency bands of R-fMRI data.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China. sophiehanying@gmail.com
FAU - Wang, Jinhui
AU  - Wang J
FAU - Zhao, Zhilian
AU  - Zhao Z
FAU - Min, Baoquan
AU  - Min B
FAU - Lu, Jie
AU  - Lu J
FAU - Li, Kuncheng
AU  - Li K
FAU - He, Yong
AU  - He Y
FAU - Jia, Jianping
AU  - Jia J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101128
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amnesia/complications/*physiopathology
MH  - *Biological Clocks
MH  - Brain/*physiopathology
MH  - Cognition Disorders/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - *Rest
EDAT- 2010/12/02 06:00
MHDA- 2011/05/14 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/11/17 00:00 [revised]
PHST- 2010/11/18 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - S1053-8119(10)01537-5 [pii]
AID - 10.1016/j.neuroimage.2010.11.059 [doi]
PST - ppublish
SO  - Neuroimage. 2011 Mar 1;55(1):287-95. doi: 10.1016/j.neuroimage.2010.11.059. Epub 
      2010 Nov 28.