PMID- 21120193
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2092-9129 (Electronic)
IS  - 1738-7949 (Print)
IS  - 1738-7949 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Jun
TI  - A variant acute promyelocytic leukemia with t(11;17) (q23;q12); ZBTB16-RARA 
      showing typical morphology of classical acute promyelocytic leukemia.
PG  - 133-5
LID - 10.5045/kjh.2010.45.2.133 [doi]
AB  - A subgroup of acute leukemia with morphology resembling acute promyelocytic 
      leukemia (APL) shows variant translocations involving RARA and has a different 
      morphology from that of classical APL. The variant APL with t(11;17)(q23;q12); 
      ZBTB16-RARA subgroup has been reported to have leukemic cells with regular 
      nuclei, many granules, absence of Auer rods, an increased number of Pelgeroid 
      neutrophils, strong myeloperoxidase (MPO) activity, and all-trans-retinoic-acid 
      (ATRA) resistance. Here, we report a case of variant APL with t(11;17)(q23;q12); 
      ZBTB16-RARA showing typical morphological features of classical APL, including 
      numerous Auer rods and faggot cells. The leukemic cells expressed CD13, CD33, 
      CD117, human leukocyte antigen (HLA)-DR, and cytoplasmic-MPO on the 
      immunophenotyping study. The diagnosis was confirmed by cytogenetic and molecular 
      studies. To distinguish variant APL cases from classical APL cases, regardless of 
      whether morphologically the findings are consistent with those of classical APL, 
      combining morphologic, immunophenotypic, cytogenetic, and molecular studies 
      before chemotherapy is very important.
FAU - Han, Sang Bong
AU  - Han SB
AD  - Department of Laboratory Medicine, College of Medicine, The Catholic University 
      of Korea, Seoul, Korea.
FAU - Lim, Jihyang
AU  - Lim J
FAU - Kim, Yonggoo
AU  - Kim Y
FAU - Kim, Hee-Je
AU  - Kim HJ
FAU - Han, Kyungja
AU  - Han K
LA  - eng
PT  - Case Reports
DEP - 20100630
PL  - Korea (South)
TA  - Korean J Hematol
JT  - The Korean journal of hematology
JID - 101486388
PMC - PMC2983015
OTO - NOTNLM
OT  - APL
OT  - PLZF
OT  - ZBTB16-RARA
OT  - t(11;17)
EDAT- 2010/12/02 06:00
MHDA- 2010/12/02 06:01
PMCR- 2010/06/01
CRDT- 2010/12/02 06:00
PHST- 2010/04/26 00:00 [received]
PHST- 2010/05/23 00:00 [revised]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2010/12/02 06:01 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 10.5045/kjh.2010.45.2.133 [doi]
PST - ppublish
SO  - Korean J Hematol. 2010 Jun;45(2):133-5. doi: 10.5045/kjh.2010.45.2.133. Epub 2010 
      Jun 30.