PMID- 21124323
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20161125
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 34
IP  - 2
DP  - 2011 Feb
TI  - Improvement in HOMA-IR is an independent predictor of reduced carotid 
      intima-media thickness in obese adolescents participating in an interdisciplinary 
      weight-loss program.
PG  - 232-8
LID - 10.1038/hr.2010.225 [doi]
AB  - The aim of this study was to verify whether a 1-year interdisciplinary 
      weight-loss program improved common carotid artery intima-media thickness (IMT) 
      and whether insulin resistance and/or inflammation (as measured by the markers 
      plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in 
      adolescents. A group of 29 post-pubescent obese adolescents were submitted to an 
      interdisciplinary intervention over the course of 1 year. Common carotid artery 
      IMT was determined ultrasonographically. Body composition, blood pressure (BP), 
      glycemia, insulinemia, homeostasis model assessment of insulin resistance 
      (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and 
      after the intervention. The interdisciplinary weight-loss program promoted a 
      significant improvement in body composition, insulin concentration, HOMA-IR, 
      lipid profile, BP and inflammatory state, in addition to significantly decreasing 
      the common carotid artery IMT. Furthermore, this study demonstrated that the 
      difference between baseline and final values of HOMA-IR (DeltaHOMA-IR) was negatively 
      correlated with concomitant changes in the adiponectin concentration 
      (Deltaadiponectin; r=-0.42; P=0.02) and positively correlated with changes in common 
      carotid artery IMT (Deltacarotid IMT; r=0.41; P=0.03). Multiple regression analysis 
      adjusted by age, cardiovascular risk factors and inflammatory markers showed that 
      DeltaHOMA-IR was an independent predictor of significant changes in common carotid 
      artery IMT. This investigation demonstrated that an interdisciplinary weight-loss 
      program promoted a reduction of the common carotid artery IMT in obese Brazilian 
      adolescents, and the improvement of HOMA-IR was an independent predictor of 
      carotid IMT changes in this population.
FAU - de Lima Sanches, Priscila
AU  - de Lima Sanches P
AD  - Post-Graduate Program of Nutrition, Universidade Federal de Sao Paulo, Sao Paulo, 
      Brazil. priscila.sanches@unifesp.br
FAU - de Mello, Marco Tulio
AU  - de Mello MT
FAU - Elias, Natalia
AU  - Elias N
FAU - Fonseca, Francisco Antonio Helfenstein
AU  - Fonseca FA
FAU - de Piano, Aline
AU  - de Piano A
FAU - Carnier, June
AU  - Carnier J
FAU - Oyama, Lila Missae
AU  - Oyama LM
FAU - Tock, Lian
AU  - Tock L
FAU - Tufik, Sergio
AU  - Tufik S
FAU - Damaso, Ana Raimunda
AU  - Damaso AR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101202
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Plasminogen Activator Inhibitor 1)
SB  - IM
MH  - Adipokines/blood
MH  - Adiponectin/blood
MH  - Adolescent
MH  - Blood Glucose/physiology
MH  - Blood Pressure/physiology
MH  - Brazil
MH  - Cardiovascular Diseases/etiology/prevention & control
MH  - *Diet, Reducing
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Obesity/diet therapy/pathology/*therapy
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Psychotherapy
MH  - Tunica Intima/*diagnostic imaging/pathology
MH  - Ultrasonography
MH  - *Weight Loss
EDAT- 2010/12/03 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - hr2010225 [pii]
AID - 10.1038/hr.2010.225 [doi]
PST - ppublish
SO  - Hypertens Res. 2011 Feb;34(2):232-8. doi: 10.1038/hr.2010.225. Epub 2010 Dec 2.