PMID- 21125730
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20181201
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 267
DP  - 2010 Oct 20
TI  - [Should we believe in the interaction between proton pump inhibitors (PPI) and 
      clopidogrel].
PG  - 1970, 1972-5
AB  - Recently, some authors have examined the possibility of an interaction between 
      proton pump inhibitors (especially omeprazole) and clopidogrel. 
      Pharmacodynamically, this interaction is proven and leads to a reduction in 
      anti-aggregation activity. Nevertheless, the clinical implications are not fully 
      clarified. We are all waiting for a randomised prospective study assessing 
      specifically this issue. Meanwhile, caution is recommended when prescribing PPI 
      in patients taking clopidogrel.
FAU - Besse, Valentina
AU  - Besse V
AD  - Service de medecine interne generale, Departement de medecine interne, HUG, 1211 
      Geneve 14. Valentina.Pelloni@hcuge.ch
FAU - Gerstel, Eric
AU  - Gerstel E
LA  - fre
PT  - Journal Article
TT  - Faut-il croire a l'interaction entre les inhibiteurs de la pompe a protons et le 
      clopidogrel?
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Aryl Hydrocarbon Hydroxylases/genetics
MH  - Clopidogrel
MH  - Cytochrome P-450 CYP2C19
MH  - Drug Interactions
MH  - Humans
MH  - Platelet Aggregation Inhibitors/*adverse effects
MH  - Polymorphism, Genetic
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Ticlopidine/adverse effects/*analogs & derivatives
EDAT- 2010/12/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Oct 20;6(267):1970, 1972-5.