PMID- 21126735
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20220316
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 69
IP  - 7
DP  - 2011 Apr 1
TI  - Individuals family history positive for alcoholism show functional magnetic 
      resonance imaging differences in reward sensitivity that are related to 
      impulsivity factors.
PG  - 675-83
LID - 10.1016/j.biopsych.2010.09.049 [doi]
AB  - BACKGROUND: Substance-abusing individuals tend to display abnormal reward 
      processing and a vulnerability to being impulsive. Detoxified alcoholics show 
      differences in regional brain activation during a monetary incentive delay task. 
      However, there is limited information on whether this uncharacteristic behavior 
      represents a biological predisposition toward alcohol abuse, a consequence of 
      chronic alcohol use, or both. METHODS: We investigated proposed neural correlates 
      of substance disorder risk by examining reward system activity during a monetary 
      incentive delay task with separate reward prospect, reward anticipation, and 
      reward outcome phases in 30 individuals with and 19 without family histories of 
      alcoholism. All subjects were healthy, lacked DSM-IV past or current alcohol or 
      substance abuse histories, and were free of illegal substances as verified by a 
      urine toxicology screening at the time of scanning. Additionally, we explored 
      specific correlations between task-related nucleus accumbens (NAcc) activation 
      and distinct factor analysis-derived domains of behavioral impulsivity. RESULTS: 
      During reward anticipation, functional magnetic resonance imaging data confirmed 
      blunted NAcc activation in family history positive subjects. In addition, we 
      found atypical activation in additional reward-associated brain regions during 
      additional task phases. We further found a significant negative correlation 
      between NAcc activation during reward anticipation and an impulsivity construct. 
      CONCLUSIONS: Overall, results demonstrate that sensitivity of the reward circuit, 
      including NAcc, is functionally different in alcoholism family history positive 
      individuals in multiple regards.
CI  - Copyright (c) 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Andrews, Melissa M
AU  - Andrews MM
AD  - Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 
      Hartford, Connecticut, USA.
FAU - Meda, Shashwath A
AU  - Meda SA
FAU - Thomas, Andre D
AU  - Thomas AD
FAU - Potenza, Marc N
AU  - Potenza MN
FAU - Krystal, John H
AU  - Krystal JH
FAU - Worhunsky, Patrick
AU  - Worhunsky P
FAU - Stevens, Michael C
AU  - Stevens MC
FAU - O'Malley, Stephanie
AU  - O'Malley S
FAU - Book, Gregory A
AU  - Book GA
FAU - Reynolds, Brady
AU  - Reynolds B
FAU - Pearlson, Godfrey D
AU  - Pearlson GD
LA  - eng
GR  - RL1 AA017539/AA/NIAAA NIH HHS/United States
GR  - R01 AA017539/AA/NIAAA NIH HHS/United States
GR  - R01 AA016599/AA/NIAAA NIH HHS/United States
GR  - R01 DA020908/DA/NIDA NIH HHS/United States
GR  - K05 AA014906/AA/NIAAA NIH HHS/United States
GR  - R01 DA020709/DA/NIDA NIH HHS/United States
GR  - R01 AA015615/AA/NIAAA NIH HHS/United States
GR  - P50 AA012870/AA/NIAAA NIH HHS/United States
GR  - R01AA016599/AA/NIAAA NIH HHS/United States
GR  - 5 P50 AA012870/AA/NIAAA NIH HHS/United States
GR  - K05 AA-14906-01/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101203
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Biol Psychiatry. 2011 Apr 1;69(7):612-3. PMID: 21397741
MH  - Adult
MH  - Alcoholism/*complications/genetics
MH  - Brain Mapping
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Impulsive Behavior/etiology/pathology/psychology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nucleus Accumbens/*blood supply
MH  - Oxygen/blood
MH  - Reaction Time
MH  - Reward
MH  - Young Adult
PMC - PMC3677031
MID - NIHMS469135
EDAT- 2010/12/04 06:00
MHDA- 2011/07/02 06:00
PMCR- 2013/06/09
CRDT- 2010/12/04 06:00
PHST- 2010/01/11 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PHST- 2013/06/09 00:00 [pmc-release]
AID - S0006-3223(10)01018-8 [pii]
AID - 10.1016/j.biopsych.2010.09.049 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2011 Apr 1;69(7):675-83. doi: 10.1016/j.biopsych.2010.09.049. 
      Epub 2010 Dec 3.