PMID- 21127322
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20211020
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 32
IP  - 14
DP  - 2011 Jul
TI  - Intracoronary autologous mononucleated bone marrow cell infusion for acute 
      myocardial infarction: results of the randomized multicenter BONAMI trial.
PG  - 1748-57
LID - 10.1093/eurheartj/ehq455 [doi]
AB  - AIMS: Intracoronary administration of autologous bone marrow cells (BMCs) leads 
      to a modest improvement in cardiac function, but the effect on myocardial 
      viability is unknown. The aim of this randomized multicentre study was to 
      evaluate the effect of BMC therapy on myocardial viability in patients with 
      decreased left ventricular ejection fraction (LVEF) after acute myocardial 
      infarction (AMI) and to identify predictive factors for improvement of myocardial 
      viability. METHODS AND RESULTS: One hundred and one patients with AMI and 
      successful reperfusion, LVEF </=45%, and decreased myocardial viability (resting 
      Tl201-SPECT) were randomized to either a control group (n = 49) or a BMC group (n 
      = 52). Primary endpoint was improvement of myocardial viability 3 months after 
      AMI. Baseline mean LVEF measured by radionuclide angiography was 36.3 +/- 6.9%. 
      Bone marrow cell infusion was performed 9.3 +/- 1.7 days after AMI. Myocardial 
      viability improved in 16/47 (34%) patients in the BMC group compared with 7/43 
      (16%) in the control group (P = 0.06). The number of non-viable segments becoming 
      viable was 0.8 +/- 1.1 in the control group and 1.2 +/- 1.5 in the BMC group (P = 
      0.13). Multivariate analysis including major post-AMI prognostic factors showed a 
      significant improvement of myocardial viability in BMC vs. control group (P = 
      0.03). Moreover, a significant adverse role for active smoking (P = 0.04) and a 
      positive trend for microvascular obstruction (P = 0.07) were observed. 
      CONCLUSION: Intracoronary autologous BMC administration to patients with 
      decreased LVEF after AMI was associated with improvement of myocardial viability 
      in multivariate-but not in univariate-analysis. A large multicentre international 
      trial is warranted to further document the efficacy of cardiac cell therapy and 
      better define a group of patients that will benefit from this therapy. CLINICAL 
      TRIAL REGISTRATION INFORMATION: URL: http://www.clinicaltrials.gov. Unique 
      identifier NCT00200707.
FAU - Roncalli, Jerome
AU  - Roncalli J
AD  - Federation de Cardiologie, CHU Toulouse, INSERM U858, Institut de Medecine 
      Moleculaire de Rangueil, Universite Paul Sabatier, Toulouse, France.
FAU - Mouquet, Frederic
AU  - Mouquet F
FAU - Piot, Christophe
AU  - Piot C
FAU - Trochu, Jean-Noel
AU  - Trochu JN
FAU - Le Corvoisier, Philippe
AU  - Le Corvoisier P
FAU - Neuder, Yannick
AU  - Neuder Y
FAU - Le Tourneau, Thierry
AU  - Le Tourneau T
FAU - Agostini, Denis
AU  - Agostini D
FAU - Gaxotte, Virginia
AU  - Gaxotte V
FAU - Sportouch, Catherine
AU  - Sportouch C
FAU - Galinier, Michel
AU  - Galinier M
FAU - Crochet, Dominique
AU  - Crochet D
FAU - Teiger, Emmanuel
AU  - Teiger E
FAU - Richard, Marie-Jeanne
AU  - Richard MJ
FAU - Polge, Anne-Sophie
AU  - Polge AS
FAU - Beregi, Jean-Paul
AU  - Beregi JP
FAU - Manrique, Alain
AU  - Manrique A
FAU - Carrie, Didier
AU  - Carrie D
FAU - Susen, Sophie
AU  - Susen S
FAU - Klein, Bernard
AU  - Klein B
FAU - Parini, Angelo
AU  - Parini A
FAU - Lamirault, Guillaume
AU  - Lamirault G
FAU - Croisille, Pierre
AU  - Croisille P
FAU - Rouard, Helene
AU  - Rouard H
FAU - Bourin, Philippe
AU  - Bourin P
FAU - Nguyen, Jean-Michel
AU  - Nguyen JM
FAU - Delasalle, Beatrice
AU  - Delasalle B
FAU - Vanzetto, Gerald
AU  - Vanzetto G
FAU - Van Belle, Eric
AU  - Van Belle E
FAU - Lemarchand, Patricia
AU  - Lemarchand P
LA  - eng
SI  - ClinicalTrials.gov/NCT00200707
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101202
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone Marrow Transplantation/*methods
MH  - Coronary Angiography
MH  - Coronary Vessels
MH  - Female
MH  - Humans
MH  - Leukocytes, Mononuclear/*transplantation
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/pathology/physiopathology/*therapy
MH  - Stroke Volume/physiology
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/pathology/physiopathology
MH  - Young Adult
PMC - PMC3386167
MID - HALMS543644
OID - NLM: HALMS543644
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2010/12/04 06:00
MHDA- 2012/01/13 06:00
PMCR- 2012/06/29
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
PHST- 2012/06/29 00:00 [pmc-release]
AID - ehq455 [pii]
AID - 10.1093/eurheartj/ehq455 [doi]
PST - ppublish
SO  - Eur Heart J. 2011 Jul;32(14):1748-57. doi: 10.1093/eurheartj/ehq455. Epub 2010 
      Dec 2.