PMID- 21127808
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20220409
IS  - 1464-0333 (Electronic)
IS  - 1464-0325 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Feb
TI  - Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension.
PG  - 241-51
LID - 10.1039/c0em00400f [doi]
AB  - Diabetes and hypertension are important contributors to morbidity and mortality 
      worldwide. Both of these conditions are caused by some combination of genetic and 
      environmental factors which may include exposure to persistent organic pollutants 
      (POPs) such as polychlorinated biphenyls (PCBs). Studies have shown an 
      association between elevated serum PCBs and the metabolic syndrome, insulin 
      sensitivity and insulin secretion. Cross-sectional studies have shown 
      associations between diabetes or hypertension and certain PCB congeners or 
      classes, while those same studies show no association between diabetes or 
      hypertension and several other PCB congeners. In animal and human cell studies, 
      various PCBs and dioxins appear to alter glucose and insulin metabolism. These 
      studies specifically show effects on the glucose transporter (GLUT-4) gene and 
      protein; insulin-like growth factor binding protein-1 (IGFBP-1); nuclear 
      transcription factor kappa B (NFkappaB); tumor necrosis factor alpha (TNF-alpha); and 
      insulin production. There are a few longitudinal studies examining the 
      association of diabetes or hypertension and PCBs with no consensus conclusion. 
      Some longitudinal studies have found there to be an association, others have not 
      and a gender difference has also been noted. Prospective studies are needed to 
      determine if PCBs and other POPs contribute to development of diabetes and 
      hypertension.
FAU - Everett, Charles Jay
AU  - Everett CJ
AD  - Department of Family Medicine, Medical University of South Carolina, 295 Calhoun 
      Street, MSC 192, Charleston, SC 29425-1920, USA. everettc@musc.edu
FAU - Frithsen, Ivar
AU  - Frithsen I
FAU - Player, Marty
AU  - Player M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101202
PL  - England
TA  - J Environ Monit
JT  - Journal of environmental monitoring : JEM
JID - 100968688
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*chemically induced
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/blood/*toxicity
MH  - Humans
MH  - Hypertension/*chemically induced
MH  - Polychlorinated Biphenyls/blood/*toxicity
EDAT- 2010/12/04 06:00
MHDA- 2011/05/19 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
AID - 10.1039/c0em00400f [doi]
PST - ppublish
SO  - J Environ Monit. 2011 Feb;13(2):241-51. doi: 10.1039/c0em00400f. Epub 2010 Dec 2.