PMID- 21129076
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20101206
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 22
IP  - 12
DP  - 2010 Dec
TI  - The evolution of proton pump inhibitors for the treatment of gastroesophageal 
      reflux disease.
PG  - 674-83
LID - 10.1111/j.1745-7599.2010.00578.x [doi]
AB  - PURPOSE: This article reviews the diagnosis and current treatment options for 
      gastroesophageal reflux disease (GERD) available to nurse practitioners, with a 
      focus on advances in proton pump inhibitor (PPI) therapy. DATA SOURCES: Review of 
      scientific literature and clinical management guidelines for GERD treatment and 
      PPI therapy from the PubMed database, Google Scholar, and other World Wide Web 
      resources. CONCLUSIONS: A number of safe and effective treatment options exist 
      for GERD. Recent developments in PPI technology may begin to address unmet needs 
      in PPI therapy. IMPLICATIONS FOR PRACTICE: GERD is commonly diagnosed and treated 
      by nurse practitioners in the primary care setting. Acid suppression therapy is 
      the primary medical therapy for GERD. PPI therapy provides symptomatic relief of 
      heartburn and regurgitation, as well as effective healing and maintenance of 
      erosive esophagitis. Newer PPIs lengthen the duration of acid suppression and 
      allow for more flexibility in dosing, which may improve medication adherence and 
      decrease episodes of acid breakthrough.
CI  - (c)2010 The Author(s) Journal compilation (c)2010 American Academy of Nurse 
      Practitioners.
FAU - Friedlander, Elizabeth A
AU  - Friedlander EA
AD  - Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. 
      efriedla@bidmc.harvard.edu
FAU - Pallentino, Julia
AU  - Pallentino J
FAU - Miller, Sally K
AU  - Miller SK
FAU - VanBeuge, Susan S
AU  - VanBeuge SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101124
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
RN  - 0 (Proton Pump Inhibitors)
MH  - Algorithms
MH  - Decision Trees
MH  - Drug Prescriptions/statistics & numerical data
MH  - Esophagitis, Peptic/etiology
MH  - Gastroenterology
MH  - Gastroesophageal Reflux/classification/complications/*diagnosis/*drug therapy
MH  - Humans
MH  - Life Style
MH  - Nurse Practitioners
MH  - Patient Selection
MH  - Practice Guidelines as Topic
MH  - Primary Health Care/methods
MH  - Proton Pump Inhibitors/pharmacology/*therapeutic use
MH  - Referral and Consultation
MH  - Severity of Illness Index
EDAT- 2010/12/07 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1745-7599.2010.00578.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2010 Dec;22(12):674-83. doi: 
      10.1111/j.1745-7599.2010.00578.x. Epub 2010 Nov 24.