PMID- 21129139
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110728
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 12
IP  - 5
DP  - 2011 Aug
TI  - Relationship of maternal weight status and weight gain rate during pregnancy to 
      the development of advanced beta cell autoimmunity in the offspring: a 
      prospective birth cohort study.
PG  - 478-84
LID - 10.1111/j.1399-5448.2010.00703.x [doi]
AB  - OBJECTIVE: This study set out to examine how maternal initial body mass index 
      (BMI) and weight gain during pregnancy associate with advanced beta cell 
      autoimmunity in the offspring. SUBJECTS: A population-based birth cohort of 4093 
      children with increased human leukocyte antigen (HLA)-conferred susceptibility to 
      type 1 diabetes (T1D) and their mothers were recruited between 1997 and 2002 in 
      two university hospital regions in Finland. METHODS: The children were monitored 
      for T1D-associated autoantibodies at 3- to 12-month intervals. Advanced beta cell 
      autoimmunity was defined as repeated positivity for islet cell antibodies and at 
      least one of the other three autoantibodies (antibodies to insulin, glutamate 
      decarboxylase and islet antigen 2). Mothers were asked to record the results of 
      the weight measurements during their first and last visits to the antenatal 
      clinic. The initial BMI and weight gain rate were calculated for each woman. 
      RESULTS: Altogether, 175 children developed advanced beta cell autoimmunity or 
      T1D during the follow-up. Maternal BMI before pregnancy or weight gain during 
      pregnancy was not associated with the end-point. Maternal vocational education 
      was associated with child's smaller risk of developing advanced beta cell 
      autoimmunity.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Arkkola, Tuula
AU  - Arkkola T
AD  - Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland. 
      tuula.arkkola@oulu.fi
FAU - Kautiainen, Susanna
AU  - Kautiainen S
FAU - Takkinen, Hanna-Mari
AU  - Takkinen HM
FAU - Kenward, Mike G
AU  - Kenward MG
FAU - Nevalainen, Jaakko
AU  - Nevalainen J
FAU - Uusitalo, Ulla
AU  - Uusitalo U
FAU - Simell, Olli
AU  - Simell O
FAU - Ilonen, Jorma
AU  - Ilonen J
FAU - Knip, Mikael
AU  - Knip M
FAU - Veijola, Riitta
AU  - Veijola R
FAU - Virtanen, Suvi M
AU  - Virtanen SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101205
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
SB  - IM
MH  - Adult
MH  - Autoimmunity/*immunology
MH  - Body Mass Index
MH  - Body Weight
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/immunology
MH  - Female
MH  - Finland
MH  - Humans
MH  - Infant, Newborn
MH  - Insulin-Secreting Cells/*immunology
MH  - Male
MH  - Pregnancy/*physiology
MH  - Prospective Studies
MH  - Weight Gain/*physiology
EDAT- 2010/12/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1399-5448.2010.00703.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2011 Aug;12(5):478-84. doi: 10.1111/j.1399-5448.2010.00703.x. 
      Epub 2010 Dec 5.