PMID- 21129331
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20211020
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 4
IP  - 6
DP  - 2010 Nov 1
TI  - Fetal risk assessment in pregnancies complicated by diabetes mellitus.
PG  - 1368-73
AB  - BACKGROUND: Hypoglycemia and hyperglycemia can pose a number of serious risks to 
      pregnant mothers with diabetes, but these risks are not always related to glucose 
      concentrations directly. Previous studies have shown the utility of using 
      mathematical transformation functions to create patient risk profiles that can 
      then be used to analyze and predict adverse outcomes in individuals with 
      diabetes. We propose a novel use of these functions to analyze the risks posed to 
      the fetus in pregnancies complicated by diabetes. METHODS: We retrospectively 
      analyzed 71 h continuous glucose monitoring system (CGMS Gold, Medtronic 
      Northridge, CA) third trimester tracings obtained during a normal pregnancy and 
      in those complicated by gestational diabetes mellitus (GDM), type 2 diabetes 
      mellitus (T2DM), and type 1 diabetes mellitus (T1DM). We then used a 
      transformation function to calculate fetal and maternal risk in each case. 
      RESULTS: In the normal pregnancy (0.93), the risk was at a minimum. Along with 
      mean glucose values, the risk increased in those cases where gestation was 
      complicated by GDM (3.12), T2DM (7.85), and T1DM (16.94). In contrast, the 
      original patient risk profile yielded a minimal value for the GDM tracings. 
      CONCLUSIONS: Total fetal risk increases from normal to GDM to T2DM to T1DM 
      pregnancies. This new risk assignment better distinguishes the stages of fetal 
      risk than the original method and therefore may be useful in future clinical 
      trials and applications to predict risk for adverse outcomes in pregnancies 
      complicated by diabetes.
CI  - (c) 2010 Diabetes Technology Society.
FAU - Zisser, Howard C
AU  - Zisser HC
AD  - Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA. 
      hzisser@sansum.org
FAU - Biersmith, Michael A
AU  - Biersmith MA
FAU - Jovanovic, Lois B
AU  - Jovanovic LB
FAU - Yogev, Yariv
AU  - Yogev Y
FAU - Hod, Moshe
AU  - Hod M
FAU - Kovatchev, Boris P
AU  - Kovatchev BP
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Diabetes Complications/blood/*etiology
MH  - Diabetes Mellitus, Type 1/blood/*complications
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - *Diabetes, Gestational/blood
MH  - Female
MH  - Fetal Diseases/blood/*etiology
MH  - Humans
MH  - Monitoring, Physiologic
MH  - Pregnancy
MH  - Pregnancy Trimester, Third/blood
MH  - *Pregnancy in Diabetics
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
PMC - PMC3005046
EDAT- 2010/12/07 06:00
MHDA- 2011/03/26 06:00
PMCR- 2011/11/01
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - dst.4.6.1368 [pii]
AID - 10.1177/193229681000400610 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2010 Nov 1;4(6):1368-73. doi: 10.1177/193229681000400610.