PMID- 21129402 OWN - NLM STAT- MEDLINE DCOM- 20110427 LR - 20220310 IS - 1872-678X (Electronic) IS - 0165-0270 (Linking) VI - 195 IP - 1 DP - 2011 Jan 30 TI - Time-resolved and time-scale adaptive measures of spike train synchrony. PG - 92-106 LID - 10.1016/j.jneumeth.2010.11.020 [doi] AB - A wide variety of approaches to estimate the degree of synchrony between two or more spike trains have been proposed. One of the most recent methods is the ISI-distance which extracts information from the interspike intervals (ISIs) by evaluating the ratio of the instantaneous firing rates. In contrast to most previously proposed measures it is parameter free and time-scale independent. However, it is not well suited to track changes in synchrony that are based on spike coincidences. Here we propose the SPIKE-distance, a complementary measure which is sensitive to spike coincidences but still shares the fundamental advantages of the ISI-distance. In particular, it is easy to visualize in a time-resolved manner and can be extended to a method that is also applicable to larger sets of spike trains. We show the merit of the SPIKE-distance using both simulated and real data. CI - Copyright (c) 2010 Elsevier B.V. All rights reserved. FAU - Kreuz, Thomas AU - Kreuz T AD - Institute for Complex Systems, Consiglio Nazionale delle Ricerche, Sesto Fiorentino, Italy. thomas.kreuz@cnr.it FAU - Chicharro, Daniel AU - Chicharro D FAU - Greschner, Martin AU - Greschner M FAU - Andrzejak, Ralph G AU - Andrzejak RG LA - eng PT - Journal Article DEP - 20101201 PL - Netherlands TA - J Neurosci Methods JT - Journal of neuroscience methods JID - 7905558 SB - IM MH - Action Potentials/*physiology MH - Animals MH - Humans MH - *Models, Neurological MH - Neural Conduction/*physiology MH - Retinal Ganglion Cells/*physiology MH - Time EDAT- 2010/12/07 06:00 MHDA- 2011/04/28 06:00 CRDT- 2010/12/07 06:00 PHST- 2010/09/17 00:00 [received] PHST- 2010/11/04 00:00 [revised] PHST- 2010/11/23 00:00 [accepted] PHST- 2010/12/07 06:00 [entrez] PHST- 2010/12/07 06:00 [pubmed] PHST- 2011/04/28 06:00 [medline] AID - S0165-0270(10)00656-4 [pii] AID - 10.1016/j.jneumeth.2010.11.020 [doi] PST - ppublish SO - J Neurosci Methods. 2011 Jan 30;195(1):92-106. doi: 10.1016/j.jneumeth.2010.11.020. Epub 2010 Dec 1.