PMID- 21129868
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20131121
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 207
IP  - 1-3
DP  - 2011 Apr 15
TI  - Detection of phentermine in hair samples from drug suspects.
PG  - e5-7
LID - 10.1016/j.forsciint.2010.11.004 [doi]
AB  - Phentermine (PT) has been widely used as an anti-obesity drug. This drug has to 
      be used with caution due to its close resemblance with amphetamines in its 
      structure and toxicity profile. Recently, PT is in distribution by illegal modes 
      and is found to be available through sources such as the internet, thus their 
      misuse and/or abuse is threatening to be a serious social issue. In the present 
      study, 32 cases of drug suspects were observed for PT abuse, detected using hair 
      samples for drug analysis. PT and other amphetamines, such as methamphetamine 
      (MA), amphetamine (AP), 3,4-methylenedioxyamphetamine (MDMA) and 
      3,4-methylenedioxyamphetamine (MDA), were extracted using 1% HCl in methanol for 
      20 h at 38 degrees C. The extracts were derivatized with trifluoroacetic anhydride (TFAA) 
      and analyzed using gas chromatography/mass spectrometry (GC/MS). Among the 32 
      cases of PT abuse, MA and its main metabolite, AP were identified in seven cases 
      and MDMA and its main metabolite, MDA were detected in two other cases.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Lee, Sooyeun
AU  - Lee S
AD  - National Institute of Scientific Investigation, 331-1 Sinwol-7-dong, 
      Yangcheon-gu, Seoul 158-707, Republic of Korea.
FAU - Kim, Jihyun
AU  - Kim J
FAU - In, Sanghwan
AU  - In S
FAU - Choi, Hwakyung
AU  - Choi H
FAU - Chung, Heesun
AU  - Chung H
FAU - Chung, Kyu Hyuck
AU  - Chung KH
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101203
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - C045TQL4WP (Phentermine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine/analysis
MH  - Central Nervous System Stimulants/*analysis
MH  - Female
MH  - Forensic Toxicology
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hair/*chemistry
MH  - Humans
MH  - Male
MH  - Methamphetamine/analysis
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis
MH  - Phentermine/*analysis
MH  - Substance Abuse Detection/*methods
MH  - Substance-Related Disorders/*diagnosis
EDAT- 2010/12/07 06:00
MHDA- 2011/09/23 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/11/02 00:00 [revised]
PHST- 2010/11/05 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - S0379-0738(10)00503-7 [pii]
AID - 10.1016/j.forsciint.2010.11.004 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2011 Apr 15;207(1-3):e5-7. doi: 
      10.1016/j.forsciint.2010.11.004. Epub 2010 Dec 3.