PMID- 21130417
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20211020
IS  - 1532-1924 (Electronic)
IS  - 1521-6926 (Print)
IS  - 1521-6926 (Linking)
VI  - 23
IP  - 4
DP  - 2010 Dec
TI  - How closely related is graft-vs-leukemia to donor/recipient disparity?
PG  - 525-8
LID - 10.1016/j.beha.2010.09.015 [doi]
AB  - Graft-vs-host disease (GVHD) is an unwanted complication of stem cell transplant, 
      but the graft-vs-leukemia (GVL) effect has been shown to positively affect 
      outcomes. GVHD and GVL have similar but not identical alloreactivity, and GVL may 
      be affected by the source of grafts, the preparative conditioning regimen, and 
      donor genetic elements. Human leukocyte antigen (HLA) mismatch does not appear to 
      augment the GVL effect, and increased GVHD does not necessarily lead to decreased 
      relapse.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Weisdorf, Daniel J
AU  - Weisdorf DJ
AD  - University of Minnesota, Minneapolis, 55455, United States. weisd001@umn.edu
LA  - eng
GR  - U24 CA076518-14/CA/NCI NIH HHS/United States
GR  - U01 HL069290/HL/NHLBI NIH HHS/United States
GR  - P01 CA111412-07/CA/NCI NIH HHS/United States
GR  - U01 HL069294/HL/NHLBI NIH HHS/United States
GR  - P01 CA111412/CA/NCI NIH HHS/United States
GR  - U01 HL069294-10/HL/NHLBI NIH HHS/United States
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U01 HL069290-10/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20101101
PL  - Netherlands
TA  - Best Pract Res Clin Haematol
JT  - Best practice & research. Clinical haematology
JID - 101120659
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Donor Selection
MH  - *Graft vs Host Disease/etiology/mortality/therapy
MH  - *Graft vs Leukemia Effect
MH  - *HLA Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Living Donors
MH  - *Stem Cell Transplantation
MH  - Transplantation, Homologous
PMC - PMC3003301
MID - NIHMS250866
COIS- Conflict of interest statement Daniel J. Weisdorf, MD Consulting Fees: Genzyme 
      Contracted Research: Genzyme
EDAT- 2010/12/07 06:00
MHDA- 2011/03/22 06:00
PMCR- 2011/12/01
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - S1521-6926(10)00076-9 [pii]
AID - 10.1016/j.beha.2010.09.015 [doi]
PST - ppublish
SO  - Best Pract Res Clin Haematol. 2010 Dec;23(4):525-8. doi: 
      10.1016/j.beha.2010.09.015. Epub 2010 Nov 1.