PMID- 21133157
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 10
IP  - 9
DP  - 2010 Sep
TI  - On the biocompatibility of Fe3O4 ferromagnetic nanoparticles with human blood 
      cells.
PG  - 6110-5
AB  - Magnetic particles are currently applied to special biomedical and environmental 
      applications owing to their unique magnetic, morphological and substance-carrying 
      capabilities. Very recently we introduced Magnetically Assisted Hemodialysis 
      (MAHD), an innovative therapeutic application of Ferromagnetic Nanoparticles 
      (FNs) for the treatment of End-Stage Renal Disease (ESRD). MAHD can be employed 
      for the selective and efficient removal of toxins that, although of high 
      biological importance, they cannot be handled by current Hemodialysis strategies. 
      This work is focused on evaluating the biocompatibility of Fe3O4 FNs with cells 
      of donated human blood, namely red blood cells (RBCs), white blood cells (WBCs) 
      and platelets (Plts). To that end, optical microscopy and atomic force microscopy 
      were employed for the morphological examination of blood cells that were 
      maturated under the presence of Fe3O4 FNs by means of mild incubation up to 120 
      min at T=20 degrees C. As a conclusion we have not detected noticeable 
      interference between RBCs, WBCs and Pits with FNs for the maturation conditions 
      and the extreme FNs concentrations examined in this work.
FAU - Stamopoulos, D
AU  - Stamopoulos D
AD  - Institute of Materials Science, NCSR Demokritos, 153-10, Aghia Paraskevi, Athens, 
      Greece.
FAU - Manios, E
AU  - Manios E
FAU - Gogola, V
AU  - Gogola V
FAU - Niarchos, D
AU  - Niarchos D
FAU - Pissas, M
AU  - Pissas M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Biocompatible Materials)
RN  - 0 (Magnetite Nanoparticles)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Biocompatible Materials/*chemistry/toxicity
MH  - *Blood Cells/cytology/drug effects
MH  - Ferrosoferric Oxide/*chemistry/therapeutic use/toxicity
MH  - Humans
MH  - In Vitro Techniques
MH  - Kidney Failure, Chronic/therapy
MH  - Magnetite Nanoparticles/*chemistry/therapeutic use/toxicity/ultrastructure
MH  - Materials Testing
MH  - Microscopy, Atomic Force
MH  - Nanotechnology
MH  - Renal Dialysis/methods
EDAT- 2010/12/08 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1166/jnn.2010.2616 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2010 Sep;10(9):6110-5. doi: 10.1166/jnn.2010.2616.