PMID- 21134002
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20220408
IS  - 1440-1789 (Electronic)
IS  - 0919-6544 (Linking)
VI  - 31
IP  - 4
DP  - 2011 Aug
TI  - Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a 
      prospective translational study on a uniformly treated cohort of adult patients.
PG  - 376-83
LID - 10.1111/j.1440-1789.2010.01178.x [doi]
AB  - Tumors from a prospective cohort of adult patients with newly diagnosed 
      glioblastoma (n=73), treated uniformly with radiochemotherapy, were examined for 
      10q23/PTEN deletion by fluorescence in situ hybridization (FISH). Statistical 
      methods were employed to evaluate the degree of association between 10q23/PTEN 
      deletion status and patient age. Survival analysis was performed using 
      Kaplan-Meier log-rank test and multivariable Cox models to assess the prognostic 
      value of 10q23/PTEN deletion. Interestingly, 10q23/PTEN homozygous deletion was 
      frequent in patients >45 years of age (P=0.034) and the median age of patients 
      harboring PTEN homozygous deletions was significantly higher than those with the 
      retained status (P=0.019). 10q23/PTEN homozygous deletion was associated with 
      shorter survival in the entire cohort as well in patients >45 years (P<0.05), 
      indicating that loss of 10q23/PTEN showed clinical importance in elderly 
      patients. Our study highlights the independent prognostic/predictive value of 
      10q23/PTEN deletion status as identified by FISH, particularly in glioblastoma 
      patients aged >45 years.
CI  - (c) 2010 Japanese Society of Neuropathology.
FAU - Srividya, Mallavarapu R
AU  - Srividya MR
AD  - Departments of Neuropathology, Neurosurgery and Biostatistics, National Institute 
      of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
FAU - Thota, Balaram
AU  - Thota B
FAU - Shailaja, Bangalore C
AU  - Shailaja BC
FAU - Arivazhagan, Arimappamagan
AU  - Arivazhagan A
FAU - Thennarasu, Kandavel
AU  - Thennarasu K
FAU - Chandramouli, Bangalore A
AU  - Chandramouli BA
FAU - Hegde, Alangar S
AU  - Hegde AS
FAU - Santosh, Vani
AU  - Santosh V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101206
PL  - Australia
TA  - Neuropathology
JT  - Neuropathology : official journal of the Japanese Society of Neuropathology
JID - 9606526
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Adult
MH  - Brain Neoplasms/*genetics/mortality
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 10
MH  - Female
MH  - Gene Dosage
MH  - Glioblastoma/*genetics/mortality
MH  - Humans
MH  - Male
MH  - PTEN Phosphohydrolase/*genetics
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Survival Analysis
EDAT- 2010/12/08 06:00
MHDA- 2011/12/14 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1440-1789.2010.01178.x [doi]
PST - ppublish
SO  - Neuropathology. 2011 Aug;31(4):376-83. doi: 10.1111/j.1440-1789.2010.01178.x. 
      Epub 2010 Dec 6.