PMID- 21138684
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20171116
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 26
IP  - 12
DP  - 2010 Dec
TI  - [The expressions of STAT3, WWOX and c-myc in human non small cell lung cancer 
      tissue and correlativity analysis].
PG  - 1203-5, 1209
AB  - AIM: To investigate the expression of STAT3, WWOX and c-myc in non small cell 
      lung cancer(NSCLC) and their clinical significance, and study their relation 
      ship. METHODS: Forty resected tissue samples from patients with NSCLC and twenty 
      normal lung tissues were subjected to immunohistochemical staining(SP) for STAT3, 
      WWOX and c-myc. RESULTS: (1)The positive expression rate of STAT3 and c-myc in 
      NSCLC were 92.5% and 90% respectively, obviously higher than normal lung tissues 
      (20% and 15%, P<0.01); The positive expression rate of WWOX was 30%, apparently 
      lower than normal lung tissues(75%, P<0.01). (2) The expression levels of STAT3 
      and c-myc were related to pathologic types in NSCLC, which in adenocarcinomas 
      were higher than squmous cell carcinomas (P<0.01), which were regardless with 
      tumor size, histodifferentiation level, clinical stage and lymphatic metastasis; 
      The expression of WWOX was ralated to whether lymph node metastasis in 
      NSCLC(P<0.01).(3) There was a negativie correlation between the expressions of 
      STAT3 and WWOX (r=-0.443, P<0.01); But no relationship was found between STAT3 
      and c-myc overexpression(r=-0.084) and between WWOX and c-myc 
      overexpression(r=0.115). CONCLUSION: STAT3 and c-myc were overexpressed in human 
      NSCLC. It indicated these proteins may make an important role in occurrence and 
      development of lung cancer.The expressions of WWOX in human NSCLC was lower, 
      which non expression was may related to the invision and metastasis of tumor. In 
      the tumorigenesis of NSCLC, there is no relationship between expression of STAT3 
      and c-myc, They played independent roles in oncogenesis of NSCLC. There was a 
      negativie correlation between the expressions of STAT3 and WWOX, but no 
      relationship was found between WWOX and c-myc.
FAU - Hu, Fu-Ying
AU  - Hu FY
AD  - Department of Respiratory Medicine, the First Peopel's Hospital of Tianmen, 
      Tianmen 431700, China. hying609@163.com
FAU - Wang, Le-Peng
AU  - Wang LP
FAU - Hou, Li-Li
AU  - Hou LL
FAU - Yin, Gang
AU  - Yin G
FAU - Wang, Hong-Cheng
AU  - Wang HC
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.1.1.- (WW Domain-Containing Oxidoreductase)
RN  - EC 1.1.1.- (WWOX protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Carcinoma, Non-Small-Cell Lung/metabolism/*pathology
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Oxidoreductases/*metabolism
MH  - Proto-Oncogene Proteins c-myc/*metabolism
MH  - STAT3 Transcription Factor/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
MH  - WW Domain-Containing Oxidoreductase
EDAT- 2010/12/09 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Dec;26(12):1203-5, 1209.