PMID- 21139707
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1936-8445 (Electronic)
IS  - 1936-8437 (Print)
IS  - 1936-8437 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Jul 16
TI  - Tumor necrosis factor-alpha-mediated severity of idiopathic retinal periphlebitis in 
      young adults (Eales' disease): implication for anti-TNF-alpha therapy.
PG  - 35-8
LID - 10.1007/s12177-010-9053-3 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic inflammatory cytokine. Tumor 
      necrosis factor-alpha was evaluated in the serum samples of patients with 
      idiopathic retinal periphlebitis in young adults (Eales' disease). Retinal 
      periphlebitis was graded according to a new grading system based on severity of 
      inflammation (grade 1-4). Quantification of the TNF-alpha levels was carried out 
      using ELISA kit in the serum samples of young adults with idiopathic retinal 
      periphlebitis (n = 17) and healthy controls (n = 17) of similar age. Tumor 
      necrosis factor-alpha level was found to be significantly raised in cases with 
      retinal periphlebitis as compared with controls (p < 0.001). Higher levels of 
      TNF-alpha were found to be associated with increased severity of retinal 
      periphlebitis. Tumor necrosis factor-alpha represents a novel target for controlling 
      inflammatory activity in idiopathic retinal periphlebitis. Higher levels of 
      TNF-alpha, in association with the increased severity of retinal periphlebitis, have 
      implications for early anti-TNF-alpha therapy.
FAU - Saxena, Sandeep
AU  - Saxena S
FAU - Pant, Aditya B
AU  - Pant AB
FAU - Khanna, Vinay K
AU  - Khanna VK
FAU - Singh, Kamlesh
AU  - Singh K
FAU - Shukla, Rajendra K
AU  - Shukla RK
FAU - Meyer, Carsten H
AU  - Meyer CH
FAU - Singh, Vijay K
AU  - Singh VK
LA  - eng
PT  - Journal Article
DEP - 20100716
PL  - United States
TA  - J Ocul Biol Dis Infor
JT  - Journal of ocular biology, diseases, and informatics
JID - 101310837
PMC - PMC2956454
OTO - NOTNLM
OT  - Anti-TNF-alpha therapy
OT  - Cytokine
OT  - Eales' disease
OT  - Idiopathic retinal periphlebitis
OT  - Tumor necrosis factor-alpha
EDAT- 2010/12/09 06:00
MHDA- 2010/12/09 06:01
PMCR- 2010/07/16
CRDT- 2010/12/09 06:00
PHST- 2010/05/29 00:00 [received]
PHST- 2010/06/28 00:00 [accepted]
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/09 06:01 [medline]
PHST- 2010/07/16 00:00 [pmc-release]
AID - 9053 [pii]
AID - 10.1007/s12177-010-9053-3 [doi]
PST - epublish
SO  - J Ocul Biol Dis Infor. 2010 Jul 16;3(1):35-8. doi: 10.1007/s12177-010-9053-3.