PMID- 21143529
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20101214
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 119
IP  - 1
DP  - 2011 Jan
TI  - Relevance of immunophenotypes to prognostic subgroups of age, WBC, platelet 
      count, and cytogenetics in de novo acute myeloid leukemia.
PG  - 76-84
LID - 10.1111/j.1600-0463.2010.02694.x [doi]
AB  - Immunophenotyping is one of the independent prognostic factors in acute myeloid 
      leukemia (AML). Relevance of immunophenotypes to prognostic subgroups of age, 
      white blood cells (WBC), platelet count, and cytogenetics in de novo AML was 
      comprehensively investigated in this study for the first time. Human leukocyte 
      antigen (HLA)-DR and CD14 expression associated with the elderly, highest WBC 
      count, and unfavorable-risk cytogenetics; CD4, CD7, and CD11b expression 
      correlated with highest WBC count and unfavorable-risk cytogenetics; CD64 
      expression was associated with higher WBC count while that of CD13 was associated 
      with lower platelet count; CD22, CD34, CD123, and terminal deoxynucleotidyl 
      transferase (TdT) expression correlated with unfavorable-risk cytogenetics; CD5 
      expression was associated with normal platelet count while that of CD19 was 
      associated with children and favorable-risk cytogenetics; CD117 expression was 
      associated with low WBC and lower platelet counts; myeloperoxidase (MPO) 
      expression correlated with lower platelet count; and MPO and glycophorin A 
      (Gly-A) expression was associated with lower WBC count and favorable-risk 
      cytogenetics. The results of the relevance analysis revealed the distribution 
      characteristics of antigen expression in different AML prognostic subgroups. The 
      majority of antigens associated with good or poor prognostic subgroups were in 
      accordance with the previous reports of correlation of expression of these 
      antigens with prognosis. Antigens associated with good (or poor) prognostic 
      subgroups were defined as good (or poor)-risk antigens.
CI  - (c) 2010 The Authors. APMIS (c) 2010 APMIS.
FAU - Li, Xiaoqing
AU  - Li X
AD  - Center for Stem Cell Research and Application, Union Hospital, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Juan
AU  - Li J
FAU - Du, Wen
AU  - Du W
FAU - Zhang, Jiahua
AU  - Zhang J
FAU - Liu, Wei
AU  - Liu W
FAU - Chen, Xiangjun
AU  - Chen X
FAU - Li, Hongrui
AU  - Li H
FAU - Huang, Shiang
AU  - Huang S
FAU - Li, Xin
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101117
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulin G)
RN  - EC 2.7.7.31 (DNA Nucleotidylexotransferase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/blood/*immunology
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - DNA Nucleotidylexotransferase/blood/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Immunophenotyping
MH  - Infant
MH  - Leukemia, Myeloid, Acute/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Young Adult
EDAT- 2010/12/15 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.1111/j.1600-0463.2010.02694.x [doi]
PST - ppublish
SO  - APMIS. 2011 Jan;119(1):76-84. doi: 10.1111/j.1600-0463.2010.02694.x. Epub 2010 
      Nov 17.