PMID- 21143753
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20140730
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 31
IP  - 1
DP  - 2011 Jan
TI  - Measurement of cardiac output with non-invasive Aesculon impedance versus 
      thermodilution.
PG  - 39-47
LID - 10.1111/j.1475-097X.2010.00977.x [doi]
AB  - BACKGROUND: This study compared the non-invasive thoracic electrical bioimpedance 
      Aesculon technique (TEB(Aesculon) ) with thermodilution (TD) to evaluate whether 
      TEB(Aesculon) may offer a reliable means for estimating cardiac output (CO) in 
      humans. MATERIAL AND METHOD: Cardiac output was measured with TD and 
      TEB(Aesculon) in 33 patients, with a mean age +/- SEM of 59 +/- 2.7 years, that 
      underwent right heart catheterization for clinical investigation of pulmonary 
      hypertension or severe heart failure. Four to five CO measurements were performed 
      with each technique simultaneously in 33 patients at rest, 11 during exercise and 
      seven during NO inhalation. RESULT: Cardiac output correlated poorly between 
      TEB(Aesculon) and TD at rest (r = 0.46, P<0.001), during exercise (r = 0.35, 
      P<0.013) and NO inhalation (r = 0.41, P<0.017). CO was higher for TEB(Aesculon) 
      than TD with 0.86 +/- 0.14 l min(-1) at rest (P<0.001) and 2.95 +/- 0.69 l min(-1) 
      during exercise (P< 0.003), but similar during NO inhalation, with a tendency (P< 
      0.079) to be 0.44 +/- 0.19 l min(-1) higher for TEB(Aesculon) than TD. CO increased 
      from rest to exercise for TEB(Aesculon) and TD with 6.11 +/- 0.6 l min(-1) 
      (P<0.001) and 3.91 +/- 0.36 l min(-1) (P<0.001), respectively; an increase that was 
      higher (P<0.002) for TEB(Aesculon) than TD. During NO inhalation, compared to 
      rest, CO decreased for TEB(Aesculon) with 0.62 +/- 0.11 l min(-1) (P<0.002), but 
      not significantly for TD with 0.21 +/- 0.12 l min(-1) (P<0.11). Bland-Altman 
      analysis showed a poor agreement between TEB(Aesculon) and TD. CONCLUSION:   
      TEB(Aesculon) overestimated CO compared to TD with  approximately 17% at rest and  approximately 34% during 
      exercise, but the techniques showed similar results during NO inhalation. CO, 
      furthermore, correlated poorly between TEB(Aesculon) and TD. TEB(Aesculon) may at 
      present not replace TD for reliable CO measurements in humans.
CI  - (c) 2010 The Authors. Clinical Physiology and Functional Imaging (c) 2010 
      Scandinavian Society of Clinical Physiology and Nuclear Medicine.
FAU - Petter, Hedelin
AU  - Petter H
AD  - GoRadLab, The Oresund Cardiovascular Research Collaboration, The Clinic for heart 
      Failure and valvular heart disease, Department of Cardiology, Lund University and 
      Skane University Hospital, Sweden. petter.hedelin@gmail.com
FAU - Erik, Agger
AU  - Erik A
FAU - Bjorn, Ekmehag
AU  - Bjorn E
FAU - Goran, Radegran
AU  - Goran R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100923
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Cardiac Catheterization/methods
MH  - Cardiac Output/*physiology
MH  - Cardiography, Impedance/*methods
MH  - Exercise/physiology
MH  - Female
MH  - Heart Failure/diagnosis
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/administration & dosage
MH  - Rest/physiology
MH  - Supine Position/physiology
MH  - Thermodilution/*methods
EDAT- 2010/12/15 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1111/j.1475-097X.2010.00977.x [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2011 Jan;31(1):39-47. doi: 
      10.1111/j.1475-097X.2010.00977.x. Epub 2010 Sep 23.