PMID- 21144996
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110118
LR  - 20220129
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 68
IP  - 5
DP  - 2010 Dec 9
TI  - Capturing VCP: another molecular piece in the ALS jigsaw puzzle.
PG  - 812-4
LID - 10.1016/j.neuron.2010.11.040 [doi]
AB  - TDP-43 mislocalization and aggregation are implicated in the pathogenesis of ALS 
      and FTLD-U. Valosin containing protein (VCP) mutations also lead to TDP-43 
      deposition, resulting in Inclusion Body Myopathy, Paget disease, and 
      Frontotemporal Dementia (IBMPFD). In this issue of Neuron, Johnson et al. used 
      whole-exome capture to identify VCP mutations in familial ALS. This extends the 
      VCP phenotype to include motor neuron degeneration and provides another molecular 
      tool to explore neurodegeneration disease mechanisms underlying the TDP-43 
      proteinopathies.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Shaw, Christopher E
AU  - Shaw CE
AD  - King's College London, MRC Centre for Neurodegeneration Research, Department of 
      Clinical Neuroscience, Institute of Psychiatry, London SE5 8AF, UK. 
      christopher.shaw@kcl.ac.uk
LA  - eng
GR  - 089701/Wellcome Trust/United Kingdom
GR  - MC_G1000733/MRC_/Medical Research Council/United Kingdom
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
CON - Neuron. 2010 Dec 9;68(5):857-64. PMID: 21145000
EDAT- 2010/12/15 06:00
MHDA- 2010/12/15 06:01
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/15 06:01 [medline]
AID - S0896-6273(10)00982-7 [pii]
AID - 10.1016/j.neuron.2010.11.040 [doi]
PST - ppublish
SO  - Neuron. 2010 Dec 9;68(5):812-4. doi: 10.1016/j.neuron.2010.11.040.