PMID- 21145007
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20220408
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 68
IP  - 5
DP  - 2010 Dec 9
TI  - Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated 
      by inhibition of SK channels.
PG  - 948-63
LID - 10.1016/j.neuron.2010.11.018 [doi]
AB  - Muscarinic receptor activation facilitates the induction of synaptic plasticity 
      and enhances cognitive function. However, the specific muscarinic receptor 
      subtype involved and the critical intracellular signaling pathways engaged have 
      remained controversial. Here, we show that the recently discovered highly 
      selective allosteric M(1) receptor agonist 77-LH-28-1 facilitates long-term 
      potentiation (LTP) induced by theta burst stimulation at Schaffer collateral 
      synapses in the hippocampus. Similarly, release of acetylcholine by stimulation 
      of cholinergic fibers facilitates LTP via activation of M(1) receptors. 
      N-methyl-D-aspartate receptor (NMDAR) opening during theta burst stimulation was 
      enhanced by M(1) receptor activation, indicating this is the mechanism for LTP 
      facilitation. M(1) receptors were found to enhance NMDAR activation by inhibiting 
      SK channels that otherwise act to hyperpolarize postsynaptic spines and inhibit 
      NMDAR opening. Thus, we describe a mechanism where M(1) receptor activation 
      inhibits SK channels, allowing enhanced NMDAR activity and leading to a 
      facilitation of LTP induction in the hippocampus.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Buchanan, Katherine A
AU  - Buchanan KA
AD  - Medical Research Council Centre for Synaptic Plasticity, School of Physiology and 
      Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK.
FAU - Petrovic, Milos M
AU  - Petrovic MM
FAU - Chamberlain, Sophie E L
AU  - Chamberlain SE
FAU - Marrion, Neil V
AU  - Marrion NV
FAU - Mellor, Jack R
AU  - Mellor JR
LA  - eng
GR  - G120/838/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (77-LH-28-1)
RN  - 0 (Muscarinic Agonists)
RN  - 0 (Piperidines)
RN  - 0 (Quinolones)
RN  - 0 (Receptor, Muscarinic M1)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Small-Conductance Calcium-Activated Potassium Channels)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
EIN - Neuron. 2011 Mar 10;69(5):1037
CIN - Neuron. 2010 Dec 9;68(5):809-11. PMID: 21144995
CIN - Nat Rev Neurosci. 2011 Feb;12(2):62. PMID: 21309090
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Feedback, Physiological
MH  - Hippocampus/cytology/metabolism
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Muscarinic Agonists/*pharmacology
MH  - Neural Inhibition/physiology
MH  - Neuronal Plasticity/physiology
MH  - Piperidines/*pharmacology
MH  - Quinolones/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor Cross-Talk/physiology
MH  - Receptor, Muscarinic M1/*drug effects/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Second Messenger Systems/physiology
MH  - Signal Transduction/physiology
MH  - Small-Conductance Calcium-Activated Potassium Channels/*metabolism
MH  - Theta Rhythm/physiology
PMC - PMC3003154
EDAT- 2010/12/15 06:00
MHDA- 2011/01/19 06:00
PMCR- 2010/12/09
CRDT- 2010/12/15 06:00
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
PHST- 2010/12/09 00:00 [pmc-release]
AID - S0896-6273(10)00934-7 [pii]
AID - 10.1016/j.neuron.2010.11.018 [doi]
PST - ppublish
SO  - Neuron. 2010 Dec 9;68(5):948-63. doi: 10.1016/j.neuron.2010.11.018.