PMID- 21145813
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20240109
IS  - 1600-0641 (Electronic)
IS  - 0168-8278 (Linking)
VI  - 54
IP  - 5
DP  - 2011 May
TI  - Interferon-lambda serum levels in hepatitis C.
PG  - 859-65
LID - 10.1016/j.jhep.2010.08.020 [doi]
AB  - BACKGROUND & AIMS: Dendritic cells (DCs) trigger adaptive immune responses and 
      are an important source of antiviral cytokines. In hepatitis C virus (HCV) 
      infection DC function is markedly impaired. Thus far, studies have focused on 
      types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 
      (IL-28A/B) serum levels in patients with different outcomes of HCV infection. 
      METHODS: IFN-lambdas were measured by ELISAs detecting IL-29 or IL-28A and 
      IL-28B, respectively. Results were stratified with respect to the recently 
      discovered rs12979860 T/C polymorphism upstream of the IL-28B gene. RESULTS: In 
      general IL-29 serum levels exceeded IL-28A/B at least twofold, with IL-29 and 
      IL-28A/B levels being significantly higher in carriers of the rs12979860 C allele 
      than in TT homozygous individuals (p<0.02). IL-29 levels were substantially lower 
      in patients with chronic hepatitis C than in healthy controls (p=0.005) and 
      patients with spontaneously resolved hepatitis (p=0.001). Patients with acute 
      hepatitis C showed IL-29 levels intermediate between chronic hepatitis C and 
      normal controls; and IL-29 serum levels were higher in patients who spontaneously 
      resolved hepatitis C than in those who became chronic. In vitro HCV proteins NS3 
      and E2 directly inhibited IL-29 production in poly I:C-stimulated purified DCs. 
      CONCLUSIONS: Our data suggest that HCV proteins modify IFN-lambda production in 
      DCs. Carriers of the rs12979860 C allele associated with resolution of HCV 
      infection exhibited increased IFN-lambda levels. Moreover, high IFN-lambda levels 
      predisposed to spontaneous resolution of HCV infection. Thus, IFN-lambdas seem to 
      play an important role in the control of hepatitis C.
CI  - Copyright (c) 2010 European Association for the Study of the Liver. Published by 
      Elsevier B.V. All rights reserved.
FAU - Langhans, Bettina
AU  - Langhans B
AD  - Department of Internal Medicine I, University of Bonn, Bonn, Germany. 
      bettina.langhans@ukb.uni-bonn.de
FAU - Kupfer, Bernd
AU  - Kupfer B
FAU - Braunschweiger, Ingrid
AU  - Braunschweiger I
FAU - Arndt, Simone
AU  - Arndt S
FAU - Schulte, Wibke
AU  - Schulte W
FAU - Nischalke, Hans Dieter
AU  - Nischalke HD
FAU - Nattermann, Jacob
AU  - Nattermann J
FAU - Oldenburg, Johannes
AU  - Oldenburg J
FAU - Sauerbruch, Tilman
AU  - Sauerbruch T
FAU - Spengler, Ulrich
AU  - Spengler U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101023
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Antigens, CD)
RN  - 0 (CD81 protein, human)
RN  - 0 (interferon-lambda, human)
RN  - 0 (Interleukins)
RN  - 0 (NS3 protein, hepatitis C virus)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Tetraspanin 28)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Nonstructural Proteins)
RN  - 157184-61-7 (glycoprotein E2, Hepatitis C virus)
RN  - 9008-11-1 (Interferons)
SB  - IM
CIN - J Hepatol. 2011 May;54(5):844-7. PMID: 21145814
MH  - Adult
MH  - Aged
MH  - Antigens, CD/immunology
MH  - Cross-Sectional Studies
MH  - Dendritic Cells/immunology
MH  - Female
MH  - Genotype
MH  - Hepacivirus/*genetics/immunology
MH  - Hepatitis C, Chronic/*immunology/*metabolism/virology
MH  - Humans
MH  - Interferons
MH  - *Interleukins/blood/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - Tetraspanin 28
MH  - Toll-Like Receptor 2/immunology
MH  - Viral Envelope Proteins/genetics
MH  - Viral Load/immunology
MH  - Viral Nonstructural Proteins/genetics
EDAT- 2010/12/15 06:00
MHDA- 2011/08/19 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/01/11 00:00 [received]
PHST- 2010/07/29 00:00 [revised]
PHST- 2010/08/04 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0168-8278(10)00922-0 [pii]
AID - 10.1016/j.jhep.2010.08.020 [doi]
PST - ppublish
SO  - J Hepatol. 2011 May;54(5):859-65. doi: 10.1016/j.jhep.2010.08.020. Epub 2010 Oct 
      23.