PMID- 21145938
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 489
IP  - 2
DP  - 2011 Feb 4
TI  - The antidepressant-like effect of human opiorphin via opioid-dependent pathways 
      in mice.
PG  - 131-5
LID - 10.1016/j.neulet.2010.12.002 [doi]
AB  - In the present study, we investigated the antidepressive activity of opiorphin 
      with central administration in the forced swim test in mice. 
      Intracerebroventricular (i.c.v.) administration of opiorphin (1-6 mug/mouse) 
      dose-dependently decreased the immobility time, which was reversed by 
      nonselective opioid receptor antagonist naloxone, delta-selective naltrindole and 
      mu-selective beta-FNA. The data suggested that central administration of opiorphin 
      produced an antidepressant-like effect by activating both mu and delta opioid 
      receptors indirectly. In order to eliminate the possibility of a false-positive 
      result in the forced swim test, locomotor activity was checked in both 
      non-habituated and habituated mice. Opiorphin had no influence on non-habituated 
      mice, though had weak effect on habituated mice. In addition, mice treated with 
      opiorphin did not display any convulsive behaviors.
CI  - Copyright A(c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Yang, Qing-Zhen
AU  - Yang QZ
AD  - Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou 
      University, 222 Tian Shui South Road, Lanzhou 730000, PR China.
FAU - Lu, Song-Song
AU  - Lu SS
FAU - Tian, Xiao-Zhu
AU  - Tian XZ
FAU - Yang, Ai-Min
AU  - Yang AM
FAU - Ge, Wan-Wen
AU  - Ge WW
FAU - Chen, Qiang
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101209
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antidepressive Agents)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, mu)
RN  - 0 (Salivary Proteins and Peptides)
RN  - 0 (glutaminyl-arginyl-phenylalanyl-seryl-arginine)
RN  - 36B82AMQ7N (Naloxone)
RN  - 5S6W795CQM (Naltrexone)
RN  - 72782-05-9 (beta-funaltrexamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Habituation, Psychophysiologic
MH  - Humans
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects
MH  - Naloxone/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Oligopeptides/administration & dosage/*pharmacology
MH  - Receptors, Opioid, delta/antagonists & inhibitors/*physiology
MH  - Receptors, Opioid, mu/antagonists & inhibitors/*physiology
MH  - Salivary Proteins and Peptides/administration & dosage/*pharmacology
MH  - Signal Transduction
EDAT- 2010/12/15 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/09/23 00:00 [received]
PHST- 2010/12/01 00:00 [revised]
PHST- 2010/12/02 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S0304-3940(10)01536-3 [pii]
AID - 10.1016/j.neulet.2010.12.002 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Feb 4;489(2):131-5. doi: 10.1016/j.neulet.2010.12.002. Epub 
      2010 Dec 9.