PMID- 21146685
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20211020
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 107
IP  - 1
DP  - 2011 Jan
TI  - Stages of systemic hypertension and blood pressure as correlates of computed 
      tomography-assessed aortic valve calcium (from the Multi-Ethnic Study of 
      Atherosclerosis).
PG  - 47-51
LID - 10.1016/j.amjcard.2010.08.042 [doi]
AB  - Hypertension has been identified as a risk factor for aortic valve calcium (AVC) 
      but the magnitude of the risk relation with hypertension severity or whether age 
      affects the strength of this risk association has not been studied. The relation 
      of hypertension severity, as defined by Joint National Committee 7 (JNC-7) 
      hypertension stages or blood pressure (BP), to computed tomographically assessed 
      AVC prevalence and severity was examined in 4,274 participants in the 
      Multi-Ethnic Study of Atherosclerosis (MESA) without treated hypertension. 
      Analyses were stratified by age < 65 or >/= 65 years, were adjusted for common 
      cardiovascular risk factors, and excluded those on antihypertensive medications. 
      In age-stratified adjusted analyses, stage I/II hypertension was associated with 
      prevalent AVC in those <65 but not in those >/= 65 years of age (odds ratio [OR] 
      2.31, 95% confidence interval [CI] 1.35 to 3.94, vs 1.33, 0.96 to 1.85, p for 
      interaction = 0.041). Similarly, systolic BP and pulse pressure were more 
      strongly associated with prevalent AVC in those <65 than in those >/= 65 years of 
      age (OR 1.21, 95% CI 1.08 to 1.35, vs 1.07, 1.01 to 1.14, per 10-mm Hg increase 
      in systolic BP, p for interaction = 0.006; and OR 1.41, 95% CI 1.21 to 1.64, vs 
      1.14, 1.05 to 1.23, per 10-mm Hg increase in pulse pressure). No associations 
      were found between hypertension stage or BP and AVC severity. In conclusion, 
      stage I/II hypertension and higher systolic BP and pulse pressure were associated 
      with prevalent AVC. These risk associations were strongest in participants < 65 
      years of age.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Linefsky, Jason
AU  - Linefsky J
AD  - University of Washington, Seattle, Washington, USA. linefsky@uw.edu
FAU - Katz, Ronit
AU  - Katz R
FAU - Budoff, Matthew
AU  - Budoff M
FAU - Probstfield, Jeffrey
AU  - Probstfield J
FAU - Owens, David
AU  - Owens D
FAU - Takasu, Junichiro
AU  - Takasu J
FAU - Shavelle, David
AU  - Shavelle D
FAU - Ouyang, Pamela
AU  - Ouyang P
FAU - Psaty, Bruce
AU  - Psaty B
FAU - O'Brien, Kevin D
AU  - O'Brien KD
LA  - eng
GR  - N01HC95169/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95159/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95169/HC/NHLBI NIH HHS/United States
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - N01 HC095159/HC/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aortic Valve
MH  - Blood Pressure
MH  - *Calcinosis
MH  - Cohort Studies
MH  - Female
MH  - Heart Valve Diseases/*physiopathology
MH  - Humans
MH  - Hypertension/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC3032359
MID - NIHMS254432
EDAT- 2010/12/15 06:00
MHDA- 2011/02/09 06:00
PMCR- 2012/01/01
CRDT- 2010/12/15 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/08/21 00:00 [revised]
PHST- 2010/08/21 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - S0002-9149(10)01725-X [pii]
AID - 10.1016/j.amjcard.2010.08.042 [doi]
PST - ppublish
SO  - Am J Cardiol. 2011 Jan;107(1):47-51. doi: 10.1016/j.amjcard.2010.08.042.