PMID- 21147367
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220409
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 30
IP  - 12
DP  - 2010 Dec
TI  - Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance.
PG  - 840-8
LID - 10.1016/j.nutres.2010.10.009 [doi]
AB  - Trehalose has been shown to evoke lower insulin secretion than glucose in oral 
      saccharide tolerance tests in humans. Given this hypoinsulinemic effect of 
      trehalose, we hypothesized that trehalose suppresses adipocyte hypertrophy by 
      reducing storage of triglyceride and mitigates insulin resistance in mice fed a 
      high-fat diet (HFD). Mice were fed an HFD and given drinking water containing 
      2.5% saccharide (glucose [Glc], trehalose [Tre], maltose [Mal], high-fructose 
      corn syrup, or fructose [Fru]) ad libitum. After 7 weeks of HFD and saccharide 
      intake, fasting serum insulin levels in the Tre/HFD group were significantly 
      lower than in the Mal/HFD and Glc/HFD groups (P < .05). Furthermore, the Tre/HFD 
      group showed a significantly suppressed elevation of homeostasis model 
      assessment-insulin resistance compared with the Mal/HFD group (P < .05) and 
      showed a trend toward lower homeostasis model assessment-insulin resistance than 
      the Glc/HFD group. After 8 weeks of feeding, mesenteric adipocyte size in the 
      Tre/HFD group showed significantly less hypertrophy than the Glc/HFD, Mal/HFD, 
      high-fructose corn syrup/HFD, or Fru/HFD group. Analysis of gene expression in 
      mesenteric adipocytes showed that no statistically significant difference in the 
      expression of monocyte chemoattractant protein-1 (MCP-1) messenger RNA (mRNA) was 
      observed between the Tre/HFD group and the distilled water/standard diet group, 
      whereas a significant increase in the MCP-1 mRNA expression was observed in the 
      Glc/HFD, Mal/HFD, Fru/HFD, and distilled water/HFD groups. Thus, our data 
      indicate that trehalose prevents adipocyte hypertrophy and mitigates insulin 
      resistance in HFD-fed mice by reducing insulin secretion and down-regulating mRNA 
      expression of MCP-1. These findings further suggest that trehalose is a 
      functional saccharide that mitigates insulin resistance.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Arai, Chikako
AU  - Arai C
AD  - Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, 
      Inc., 675-1 Fujisaki, Okayama 702-8006, Japan. fujisaki@hayashibara.co.jp
FAU - Arai, Norie
AU  - Arai N
FAU - Mizote, Akiko
AU  - Mizote A
FAU - Kohno, Keizo
AU  - Kohno K
FAU - Iwaki, Kanso
AU  - Iwaki K
FAU - Hanaya, Toshiharu
AU  - Hanaya T
FAU - Arai, Shigeyuki
AU  - Arai S
FAU - Ushio, Simpei
AU  - Ushio S
FAU - Fukuda, Shigeharu
AU  - Fukuda S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
RN  - B8WCK70T7I (Trehalose)
SB  - IM
MH  - Adipocytes/*drug effects/pathology
MH  - Animals
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Dietary Fats/adverse effects
MH  - Dietary Sucrose/*administration & dosage
MH  - Female
MH  - Gene Expression/drug effects
MH  - Hypertrophy
MH  - Insulin/*blood
MH  - Insulin Resistance/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/drug therapy/metabolism/pathology/*physiopathology
MH  - RNA, Messenger/metabolism
MH  - Trehalose/*pharmacology/therapeutic use
EDAT- 2010/12/15 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/07/28 00:00 [received]
PHST- 2010/10/08 00:00 [revised]
PHST- 2010/10/12 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - S0271-5317(10)00210-1 [pii]
AID - 10.1016/j.nutres.2010.10.009 [doi]
PST - ppublish
SO  - Nutr Res. 2010 Dec;30(12):840-8. doi: 10.1016/j.nutres.2010.10.009.