PMID- 21147819
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20131121
IS  - 1552-695X (Electronic)
IS  - 1534-7354 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Mar
TI  - Exercise in patients with breast cancer and healthy controls: energy substrate 
      oxidation and blood lactate responses.
PG  - 6-15
LID - 10.1177/1534735410387600 [doi]
AB  - The aim of this study was to compare select aspects of exercise energy metabolism 
      in patients with breast cancer with that of healthy controls across a variety of 
      exercise intensities. Posttreated patients with breast cancer were matched with 
      healthy women based on age, physical fitness level, and menopausal status. 
      Subjects participated in low-, moderate-, and high-intensity submaximal exercise 
      sessions that corresponded with 40% of maximal oxygen consumption (Vo(2max)), 60% 
      Vo(2max), and 70% Vo(2max). Oxygen consumption and respiratory exchange ratio 
      were taken during submaximal exercise sessions to determine substrate oxidation 
      rates for carbohydrate (CHO) and fat. Blood lactate and blood glucose were also 
      measured before and after each of the submaximal exercise sessions as indices of 
      CHO metabolism. Results indicate that the patients with breast cancer had a 
      significantly (P</=.05) lower CHO oxidation rate and higher fat oxidation rate at 
      all exercise intensities compared with healthy women. The patients with breast 
      cancer had a significantly (P</=.05) lower blood lactate response to exercise 
      across all intensities compared with the healthy women. Glucose responses tended 
      (P<.08) to be more elevated in patients with cancer both before and after the 
      exercise sessions. The findings indicate that posttreated patients with breast 
      cancer have augmented fat metabolism and a reduced CHO-based energy metabolism 
      during submaximal exercise. It is unclear whether these changes are the result of 
      the patient's cancer or their treatment regimen for the cancer.
CI  - (c) The Author(s) 2011
FAU - Tosti, Karen P
AU  - Tosti KP
AD  - University of North Carolina, Chapel Hill, NC 27599, USA.
FAU - Hackney, Anthony C
AU  - Hackney AC
FAU - Battaglini, Claudio L
AU  - Battaglini CL
FAU - Evans, Elizabeth S
AU  - Evans ES
FAU - Groff, Diane
AU  - Groff D
LA  - eng
PT  - Journal Article
DEP - 20101208
PL  - United States
TA  - Integr Cancer Ther
JT  - Integrative cancer therapies
JID - 101128834
RN  - 0 (Blood Glucose)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Breast Neoplasms/blood/*metabolism
MH  - Carbohydrate Metabolism/physiology
MH  - Case-Control Studies
MH  - Energy Metabolism/physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Lactic Acid/*blood
MH  - Lipid Metabolism/physiology
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/physiology
MH  - Respiratory Function Tests
EDAT- 2010/12/15 06:00
MHDA- 2011/08/05 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 1534735410387600 [pii]
AID - 10.1177/1534735410387600 [doi]
PST - ppublish
SO  - Integr Cancer Ther. 2011 Mar;10(1):6-15. doi: 10.1177/1534735410387600. Epub 2010 
      Dec 8.