PMID- 21147820
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Mar
TI  - Determinants of extracellular matrix remodelling are differentially expressed in 
      paediatric and adult dilated cardiomyopathy.
PG  - 271-7
LID - 10.1093/eurjhf/hfq184 [doi]
AB  - AIMS: The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) 
      can appear similar in paediatric and adult patients. However, the aetiology of 
      paediatric DCM is usually idiopathic, and often leads an aggressive clinical 
      course. A structural underpinning of DCM is extracellular matrix changes, which 
      are determined by a balance between matrix metalloproteinases (MMPs) and tissue 
      inhibitors of MMPs (TIMPs). This study tested the hypothesis that different 
      MMP/TIMP profiles occur in paediatric and adult DCM patients. METHODS AND 
      RESULTS: Left ventricular samples from paediatric (age 9 +/- 5 years; n = 10) and 
      adult (age 62 +/- 3 years; n = 20) DCM (at time of transplant) were subjected to an 
      MMP/TIMP multiplex array and immunoassay in order to measure the MMP subclasses; 
      collagenases (MMP-8, -13), gelatinases (MMP-2, -9), stromelysin/matrilysin 
      (MMP-3, -7), membrane type (MT1-MMP), as well as for the four known TIMPs. MMP-8 
      and -9 levels increased by over 150% (P < 0.05), whereas MMP-3 and -7 levels 
      decreased by over 30% (P < 0.05) in paediatric DCM when compared with adult DCM. 
      TIMP-1 and -2 levels increased two-fold (P < 0.05), but TIMP-3 fell by 41% (P < 
      0.05) in paediatric DCM. Myocardial levels of specific interleukins (IL-1beta, 
      IL-2, IL-8) were increased by approximately 50% in paediatric DCM. CONCLUSIONS: 
      These unique findings demonstrated that a specific MMP/TIMP profile occurs in 
      paediatric DCM when compared with adult DCM, and that local cytokine induction 
      may contribute to this process. These distinct differences in the determinants of 
      myocardial matrix structure and function may contribute to the natural history of 
      DCM in children.
FAU - Hsia, Tain-Yen
AU  - Hsia TY
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 114 
      Doughty Street, Charleston, SC 29403, USA.
FAU - Ringewald, Jeremy M
AU  - Ringewald JM
FAU - Stroud, Robert E
AU  - Stroud RE
FAU - Forbus, Geoffrey A
AU  - Forbus GA
FAU - Bradley, Scott M
AU  - Bradley SM
FAU - Chung, Wendy K
AU  - Chung WK
FAU - Spinale, Francis G
AU  - Spinale FG
LA  - eng
GR  - HL057952-08/HL/NHLBI NIH HHS/United States
GR  - HL059165-09/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101208
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Cytokines)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*metabolism/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/metabolism
MH  - Extracellular Matrix/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinases/*metabolism
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
PMC - PMC3041467
EDAT- 2010/12/15 06:00
MHDA- 2011/06/24 06:00
PMCR- 2012/03/01
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - hfq184 [pii]
AID - 10.1093/eurjhf/hfq184 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2011 Mar;13(3):271-7. doi: 10.1093/eurjhf/hfq184. Epub 2010 Dec 
      8.