PMID- 21148717
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Print)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 1
DP  - 2011 Jan
TI  - The inter- and intragenerational impact of gestational diabetes on the epidemic 
      of type 2 diabetes.
PG  - 173-9
LID - 10.2105/AJPH.2009.186890 [doi]
AB  - OBJECTIVES: We investigated the contribution of gestational diabetes mellitus 
      (GDM) to the historic epidemic of type 2 diabetes mellitus (T2DM) in 
      Saskatchewan. METHODS: We constructed a population-level simulation model of the 
      inter- and intragenerational interaction of GDM and T2DM for the period 1956 to 
      2006. The model was stratified by gender, ethnicity, and age; parameterized with 
      primary and secondary data; and calibrated to match historic time series. Risk of 
      diabetes was sigmoidally trended to capture exogenous factors. RESULTS: Best-fit 
      calibrations suggested GDM may be responsible for 19% to 30% of the cases of T2DM 
      among Saskatchewan First Nations people, but only for approximately 6% of cases 
      among other persons living in Saskatchewan. The estimated contribution of GDM to 
      the growth in T2DM was highly sensitive to assumptions concerning the post-GDM 
      risk of developing T2DM. CONCLUSIONS: GDM may be an important driver for the T2DM 
      epidemic in many subpopulations. Because GDM is a readily identifiable, 
      preventable, and treatable condition, investments in prevention, rapid diagnosis, 
      and evidence-based treatment of GDM in at-risk populations may offer substantial 
      benefit in lowering the T2DM burden over many generations. Model-informed data 
      collection can aid in assessing intervention tradeoffs.
FAU - Osgood, Nathaniel D
AU  - Osgood ND
AD  - Department of Computer Science, University of Saskatchewan, Saskatoon, SK, 
      Canada. nathaniel.osgood@usask.ca
FAU - Dyck, Roland F
AU  - Dyck RF
FAU - Grassmann, Winfried K
AU  - Grassmann WK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*ethnology
MH  - Diabetes, Gestational/*ethnology
MH  - Family Health
MH  - Female
MH  - Humans
MH  - *Indians, North American
MH  - *Intergenerational Relations
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Pregnancy
MH  - Prevalence
MH  - Risk Factors
MH  - Saskatchewan/epidemiology
PMC - PMC3000710
EDAT- 2010/12/15 06:00
MHDA- 2011/01/21 06:00
PMCR- 2013/01/01
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 101/1/173 [pii]
AID - 186890 [pii]
AID - 10.2105/AJPH.2009.186890 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Jan;101(1):173-9. doi: 10.2105/AJPH.2009.186890.