PMID- 21149633
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 117
IP  - 12
DP  - 2011 Mar 24
TI  - Influence of infused cell dose and HLA match on engraftment after double-unit 
      cord blood allografts.
PG  - 3277-85; quiz 3478
LID - 10.1182/blood-2010-08-300491 [doi]
AB  - The influence of cell dose and human leukocyte antigen (HLA) match on double-unit 
      cord blood (CB) engraftment is not established. Therefore, we analyzed the impact 
      of cell dose and high-resolution HLA match on neutrophil engraftment in 84 
      double-unit CB transplant recipients. The 94% sustained engraftment rate was 
      accounted for by 1 unit in nearly all patients. Higher CD3(+) cell doses (P = 
      .04) and percentage of CD34(+) cell viability (P = .008) were associated with 
      unit dominance. After myeloablative conditioning, higher dominant unit total 
      nucleated cell (TNC), CD34(+) cell, and colony-forming unit doses were associated 
      with higher sustained engraftment and faster neutrophil recovery (P = .07, P = 
      .0008, and P < .0001, respectively). Total infused TNC (P = .0007) and CD3(+) 
      cell doses (P = .001) also significantly influenced engraftment. At 
      high-resolution extensive donor-recipient HLA disparity was frequent, but had no 
      influence on engraftment (P = .66), or unit dominance (P = .13). Although the 
      unit-unit HLA match also did not affect sustained engraftment (P = 1.0), 
      recipients of units closely (7-10 to 10-10) HLA-matched to each other were more 
      likely to demonstrate initial engraftment of both units (P < .0001). Our findings 
      have important implications for unit selection and provide further insight into 
      double-unit biology.
FAU - Avery, Sharon
AU  - Avery S
AD  - Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial 
      Sloan-Kettering Cancer Center, New York, NY 10065, USA.
FAU - Shi, Weiji
AU  - Shi W
FAU - Lubin, Marissa
AU  - Lubin M
FAU - Gonzales, Anne Marie
AU  - Gonzales AM
FAU - Heller, Glenn
AU  - Heller G
FAU - Castro-Malaspina, Hugo
AU  - Castro-Malaspina H
FAU - Giralt, Sergio
AU  - Giralt S
FAU - Kernan, Nancy A
AU  - Kernan NA
FAU - Scaradavou, Andromachi
AU  - Scaradavou A
FAU - Barker, Juliet N
AU  - Barker JN
LA  - eng
GR  - P01 CA023766/CA/NCI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - P01 CA23766/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101213
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Blood. 2011 Mar 24;117(12):3248-9. PMID: 21436075
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cell Count
MH  - Child
MH  - Child, Preschool
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Graft Survival/immunology
MH  - HLA Antigens/analysis
MH  - Hematopoietic Stem Cells/*cytology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Infant
MH  - Infusions, Intravenous
MH  - Middle Aged
MH  - Neutrophils/immunology
MH  - Transplantation, Homologous/immunology
MH  - Young Adult
PMC - PMC3069669
EDAT- 2010/12/15 06:00
MHDA- 2011/06/07 06:00
PMCR- 2012/03/24
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PHST- 2012/03/24 00:00 [pmc-release]
AID - S0006-4971(20)36492-2 [pii]
AID - 2010/300491 [pii]
AID - 10.1182/blood-2010-08-300491 [doi]
PST - ppublish
SO  - Blood. 2011 Mar 24;117(12):3277-85; quiz 3478. doi: 10.1182/blood-2010-08-300491. 
      Epub 2010 Dec 13.