PMID- 2114999
OWN - NLM
STAT- MEDLINE
DCOM- 19900823
LR  - 20081121
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 20
IP  - 6
DP  - 1990 Jun
TI  - Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups.
PG  - 1317-25
AB  - Comparison of 60 human immunoglobulin variable lambda (IGLV) sequences allowed us 
      to define seven subgroups designated V lambda I to V lambda VII. We demonstrate 
      that all lambda proteins sequenced so far fall into the subgroups I, II, III and 
      VI, and that the lambda regions previously assigned to subgroups IV and V belong, 
      in fact, to subgroups III and II, respectively. Four sequences not belonging to 
      any of the subgroups I, II, III and VI define the new subgroups IV, V and VII. 
      Interestingly, these subgroups show a higher homology to rabbit or mouse V lambda 
      genes than to the other human V lambda subgroups. By comparison of the proteins 
      either with the sequences deduced from the germ-line genes or with the consensus 
      sequences, the rate of amino acid changes due to somatic mutations or allelic 
      variations was evaluated in several lambda proteins. Framework and 
      complementarity-determining regions of the human IGLV genes and proteins were 
      delineated. Alignment of the lambda sequences shows that functional V-J 
      rearrangement occurs, with or without deletion of nucleotides encoding one or two 
      amino acids at the 3' end of the V gene. Diversity of the third 
      complementarity-determining region is due to somatic mutations and to flexible 
      V-J junction, but there is no evidence of N-diversity in the human lambda locus.
FAU - Chuchana, P
AU  - Chuchana P
AD  - Laboratoire d'Immunogenetique Moleculaire, URA CNRS, Universite Montpellier II, 
      France.
FAU - Blancher, A
AU  - Blancher A
FAU - Brockly, F
AU  - Brockly F
FAU - Alexandre, D
AU  - Alexandre D
FAU - Lefranc, G
AU  - Lefranc G
FAU - Lefranc, M P
AU  - Lefranc MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Immunoglobulin J-Chains)
RN  - 0 (Immunoglobulin Joining Region)
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Immunoglobulin lambda-Chains)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Amyloidosis/immunology
MH  - Animals
MH  - Genetic Variation
MH  - Humans
MH  - Immunoglobulin Isotypes/genetics
MH  - Immunoglobulin J-Chains/genetics
MH  - Immunoglobulin Joining Region/genetics
MH  - Immunoglobulin Variable Region/*genetics
MH  - Immunoglobulin lambda-Chains/*genetics
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Sequence Homology, Nucleic Acid
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1002/eji.1830200618 [doi]
PST - ppublish
SO  - Eur J Immunol. 1990 Jun;20(6):1317-25. doi: 10.1002/eji.1830200618.