PMID- 21150146
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20101214
IS  - 0091-3847 (Print)
IS  - 0091-3847 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Dec
TI  - Risk factors and asthma phenotypes in children and adults with seasonal allergic 
      rhinitis.
PG  - 81-6
LID - 10.3810/psm.2010.12.1829 [doi]
AB  - BACKGROUND: There are few data on asthma risk factors and phenotypes in patients 
      with seasonal allergic rhinitis (SAR). METHODS: Thirty-three children (mean age, 
      8.27 +/- 1.77 years) and 82 adults (mean age, 34.12 +/- 10.59 years) with SAR were 
      evaluated for asthma (history, reversibility of bronchial obstruction, increased 
      inhaled nitric oxide). The following asthma risk factors were considered in the 
      multiple regression analysis: male sex, family history of asthma, breastfeeding < 
      2 months, passive/active smoking, obesity, pets/molds exposure, high total serum 
      immunoglobulin E (IgE), polysensitization (sensitized to 3 seasonal pollens with 
      different structure), mixed sensitization (seasonal and perennial allergens), 
      severe rhinitis (according to the Allergic Rhinitis and its Impact on Asthma 
      guidelines), and lack of allergen-specific immunotherapy (SIT) for rhinitis 
      preceding asthma diagnosis. Asthma phenotypes were characterized using the 
      k-means clustering (silhouette method for cluster validation). RESULTS: Asthma 
      was diagnosed in 22 (66.7%) children and in 57 (69.5%) adults with SAR. 
      Independent risk factors for asthma were lack of SIT preceding asthma diagnosis, 
      both for children (P = 0.008132) and adults (P = 0.000017), and mixed 
      sensitization for children (P = 0.035694). Asthma phenotypes identified in 
      children according to the associated risk factors were: breastfeeding < 2 months 
      and severe rhinitis in 16 (63.6%) patients; male, polysensitized, and severe 
      rhinitis in 8 (36.4%) patients. Asthma phenotypes in adults were: 
      polysensitization and severe rhinitis in 30 (52.6%) patients; male, exposure to 
      pets, and severe rhinitis in 11 (19.3%) patients; and high total serum IgE and 
      polysensitization in 16 (28.1%) patients. CONCLUSION: Lack of SIT is an 
      independent risk factor for asthma both in children and adults with SAR, whereas 
      polysensitization is a risk factor only for children. The dominant asthma 
      phenotype in children with SAR is breastfeeding < 2 months and severe rhinitis. 
      In adults with SAR, the dominant asthma phenotype is polysensitization and severe 
      rhinitis.
FAU - Agache, Ioana
AU  - Agache I
AD  - Transylvania University, Brasov, Romania. ibrumaru@unitbv.ro
FAU - Ciobanu, Cristina
AU  - Ciobanu C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Phys Sportsmed
JT  - The Physician and sportsmedicine
JID - 0427461
SB  - IM
MH  - Adult
MH  - Asthma/*diagnosis/*etiology/*physiopathology
MH  - Bronchial Provocation Tests
MH  - Child
MH  - Child, Preschool
MH  - Cluster Analysis
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - Regression Analysis
MH  - Rhinitis, Allergic, Seasonal/*complications/*diagnosis/*physiopathology
MH  - Risk Factors
EDAT- 2010/12/15 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.3810/psm.2010.12.1829 [doi]
PST - ppublish
SO  - Phys Sportsmed. 2010 Dec;38(4):81-6. doi: 10.3810/psm.2010.12.1829.