PMID- 21150383
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20161125
IS  - 2331-2637 (Electronic)
IS  - 1074-7931 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Nov
TI  - An analysis of changes in cerebral blood flood velocities in depressive 
      pseudo-dementia and Alzheimer disease patients.
PG  - 358-63
LID - 10.1097/NRL.0b013e3181a2eace [doi]
AB  - BACKGROUND: Patients with pseudo-dementia are at particular risk of being labeled 
      as Alzheimer dementia. We thus need better diagnostic methods. In this study, we 
      evaluated the cerebral reactivity of the posterior cerebral arteries (PCAs) 
      during visual stimulation by transcranial Doppler ultrasonography. METHODS: The 
      study group consisted of 13 and 11 patients suffering from pseudo-dementia and 
      Alzheimer disease (AD), respectively, and 10 healthy controls. Visual reactivity 
      was defined as the differences of cerebral blood flow velocity (CBFv) against the 
      visual stimulus. Mini Mental State Examination and Montgomery-Asberg Depression 
      Rating Scales were used as psychometric tests. The transcranial Doppler 
      ultrasonography device was applied for simultaneous recording of both PCAs. 
      Obtained data were evaluated by Student t test, and 1-way analysis of variance 
      tests, with a priori as P<0.05. RESULTS: Subjects with AD had a lower CBFv 
      following visual stimuli (P<0.001). Mean CBFv throughout the procedure [P<0.001; 
      right and left sides, in AD and depressive pseudo-dementia (DPD), respectively], 
      velocity at rest (P<0.001 in each side for both groups), and velocity at 
      stimulation (P<0.001; each side for both groups) on both PCAs were significantly 
      lower in patients with AD and DPD than those of the controls. Compared with the 
      controls, the relative (r) CBFvs (%) were found to be significantly lower in AD 
      (P<0.05, P<0.01, for the right and left side, respectively). CONCLUSIONS: We have 
      shown that CBFv decreased in patients with AD and DPD, but vasoneuronal activity 
      was only impaired in patients with AD. On the other hand, although the results do 
      not show significant differences between depressive and demented groups by TCD, 
      further studies will be needed for differentiating these diseases.
FAU - Gucuyener, Demet Ozbabalik
AU  - Gucuyener DO
AD  - Department of Neurology, Osmangazi University, Meselik-Eskisehir, Turkey.
FAU - Yenilmez, Cinar
AU  - Yenilmez C
FAU - Ayranci, Unal
AU  - Ayranci U
FAU - Ozdemir, Figen
AU  - Ozdemir F
FAU - Uzuner, Nevzat
AU  - Uzuner N
FAU - Ozkan, Serhat
AU  - Ozkan S
FAU - Kaptanoglu, Cem
AU  - Kaptanoglu C
FAU - Ozdemir, Gazi
AU  - Ozdemir G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurologist
JT  - The neurologist
JID - 9503763
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*physiopathology
MH  - *Blood Flow Velocity
MH  - Cerebrovascular Circulation/*physiology
MH  - Depressive Disorder/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Posterior Cerebral Artery/diagnostic imaging/*physiopathology
MH  - *Regional Blood Flow
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2010/12/15 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - 00127893-201011000-00004 [pii]
AID - 10.1097/NRL.0b013e3181a2eace [doi]
PST - ppublish
SO  - Neurologist. 2010 Nov;16(6):358-63. doi: 10.1097/NRL.0b013e3181a2eace.